RNA interference of PHB1 enhances virulence of Vip3Aa to Sf9 cells and Spodoptera frugiperda larvae.
Sign Up to like & getrecommendations! Published in 2023 at "Pest management science"
DOI: 10.1002/ps.7469
Abstract: BACKGROUND In our previous work, we demonstrated that prohibitin 2 (PHB2) on the membrane of Sf9 cells was a receptor for Vip3Aa, and PHB2 in mitochondria contributed to the mitochondrial stability to reduce Vip3Aa toxicity.… read more here.
Keywords: phb1; frugiperda larvae; sf9 cells; virulence ... See more keywords
Regulatory effects of Prohibitin 1 on proliferation and apoptosis of pulmonary arterial smooth muscle cells in monocrotaline-induced PAH rats.
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DOI: 10.1016/j.lfs.2020.117548
Abstract: BACKGROUND Pulmonary arterial hypertension (PAH) is a severe pulmonary vascular disease characterized by unbalanced proliferation and apoptosis of pulmonary arterial smooth muscle cells (PASMCs). Prohibitin 1 (PHB1) is known for its significant anti-proliferative activity. However,… read more here.
Keywords: proliferation apoptosis; proliferation; pulmonary arterial; phb1 ... See more keywords
Nuclear partitioning of Prohibitin 1 inhibits Wnt/β-catenin-dependent intestinal tumorigenesis
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DOI: 10.1038/s41388-020-01538-y
Abstract: The Wnt/β-catenin signaling pathway is aberrantly activated in the majority of colorectal cancer cases due to somatic mutations in the adenomatous polyposis coli ( APC ) gene. Prohibitin 1 (PHB1) serves pleiotropic cellular functions with… read more here.
Keywords: prohibitin; phb1; wnt catenin; intestinal tumorigenesis ... See more keywords
Saturated Fatty Acid-Induced Impairment of Hepatic Lipid Metabolism Is Worsened by Prohibitin 1 Deficiency in Hepatocytes.
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DOI: 10.1089/jmf.2022.k.0028
Abstract: Obesity-associated nonalcoholic fatty liver disease (NAFLD) is characterized by excessive intrahepatic lipid accumulation. Despite the increasing prevalence of NAFLD and obesity, the pathogenesis of NAFLD has not yet been clearly elucidated. Prohibitin 1 (PHB1) is… read more here.
Keywords: metabolism; phb1; lipid metabolism; mrna levels ... See more keywords
Hepatocyte PHB1 Deficiency Causes Sex-Specific Changes in Glycemic Control and Body Composition in Mice
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DOI: 10.1152/physiol.2023.38.s1.5733979
Abstract: Prohibitin 1 (PHB1) is a dynamic lipid raft associated protein that is located in plasma membrane and in the inner mitochondrial membrane complexed with its homolog PHB2 in a tight 1:1 stoichiometric ratio. The PHB1/2… read more here.
Keywords: phb1; hphb1def mice; hepatocyte phb1; physiology ... See more keywords
Endothelial Prohibitin Mediates Bi-directional Long Chain Fatty Acid Transport in White and Brown Adipose Tissues.
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DOI: 10.2337/db21-0972
Abstract: The function of Prohibitin-1 (PHB1) in adipocyte mitochondrial respiration, adaptive thermogenesis, and long chain fatty acid (LCFA) metabolism has been reported. While intracellular PHB1 expression is ubiquitous, cell surface PHB1 localization is selective for adipocytes… read more here.
Keywords: chain fatty; phb1 mice; phb1; long chain ... See more keywords