The expression of PHB2 in the cochlea: possible relation to age-related hearing loss.
Sign Up to like & getrecommendations! Published in 2021 at "Cell biology international"
DOI: 10.1002/cbin.11693
Abstract: Age-related hearing loss (ARHL) is the most prevalent sensory deficit in the elderly, but its mechanism remains unclear. Scaffold protein Prohibitin 2 (PHB2) has been widely involved in aging and neurodegeneration. However, the role of… read more here.
Keywords: hearing loss; age related; related hearing; phb2 ... See more keywords
The survival and proliferation of osteosarcoma cells are dependent on the mitochondrial BIG3‐PHB2 complex formation
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Science"
DOI: 10.1111/cas.15099
Abstract: Previous studies reported the critical role of the brefeldin A–inhibited guanine nucleotide exchange protein 3–prohibitin 2 (BIG3‐PHB2) complex in modulating estrogen signaling activation in breast cancer cells, yet its pathophysiological roles in osteosarcoma (OS) cells… read more here.
Keywords: complex formation; phb2; big3 phb2; osteosarcoma cells ... See more keywords
Artemisinin Alleviates Cerebral Ischemia/Reperfusion-Induced Oxidative Damage via Regulating PHB2-Mediated Autophagy in the Human Neuroblastoma SH-SY5Y Cell Line
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/6568748
Abstract: Oxidative stress plays a key role in cerebral ischemia/reperfusion injury. Artemisinin (ART) has antioxidative stress activity in addition to its powerful antimalarial effects. In this article, we investigated the effect of ART on OGD/R-induced oxidative… read more here.
Keywords: stress; damage; oxidative stress; induced oxidative ... See more keywords
Nonreceptor Tyrosine Kinase c-Abl-Mediated PHB2 Phosphorylation Aggravates Mitophagy Disorder in Parkinson's Disease Model
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/9233749
Abstract: Mitophagy and oxidative stress play important roles in Parkinson's disease (PD). Dysregulated mitophagy exacerbates mitochondrial oxidative damage; however, the regulatory mechanism of mitophagy is unclear. Here, we provide a potential mechanistic link between c-Abl, a… read more here.
Keywords: parkinson disease; abl; phb2; tyrosine kinase ... See more keywords
Mitochondrial Aurora kinase A induces mitophagy by interacting with MAP1LC3 and Prohibitin 2
Sign Up to like & getrecommendations! Published in 2021 at "Life Science Alliance"
DOI: 10.26508/lsa.202000806
Abstract: The multifunctional Ser/Thr kinase AURKA uses the Inner Mitochondrial Membrane receptor PHB2 and MAP1LC3 as a signalling platform to orchestrate the elimination of dysfunctional mitochondria. Epithelial and haematologic tumours often show the overexpression of the… read more here.
Keywords: kinase; phb2; inner mitochondrial; tripartite complex ... See more keywords
Inhibition of Prolyl Oligopeptidase Restores Prohibitin 2 Levels in Psychosis Models: Relationship to Cognitive Deficits in Schizophrenia
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076016
Abstract: Cognitive impairment represents one of the core features of schizophrenia. Prolyl Oligopeptidase (POP) inhibition is an emerging strategy for compensating cognitive deficits in hypoglutamatergic states such as schizophrenia, although little is known about how POP… read more here.
Keywords: phb2 levels; inhibition; cognitive deficits; prolyl oligopeptidase ... See more keywords
Functional role and molecular mechanisms underlying prohibitin 2 in platelet mitophagy and activation
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DOI: 10.3892/mmr.2021.12023
Abstract: Platelet mitophagy is a major pathway involved in the clearance of injured mitochondria during hemostasis and thrombosis. Prohibitin 2 (PHB2) has recently emerged as an inner mitochondrial membrane receptor involved in mitophagy. However, the mechanisms… read more here.
Keywords: platelet mitophagy; mitophagy activation; phb2; mitophagy ... See more keywords
Bax inhibitor 1 preserves mitochondrial homeostasis in acute kidney injury through promoting mitochondrial retention of PHB2
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DOI: 10.7150/thno.40098
Abstract: Bax inhibitor-1 (BI1) conveys anti-apoptotic signals for mitochondria while prohibitin 2 (PHB2) is implicated in sustaining mitochondrial morphology and function. However, their regulatory roles in acute kidney injury (AKI) are largely unknown. Methods: In human… read more here.
Keywords: kidney injury; bi1; phb2; acute kidney ... See more keywords