Hsp90 Co‐chaperone p23 contributes to dopaminergic mitochondrial stress via stabilization of PHD2: Implications for Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2018 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2018.02.012
Abstract: HighlightsMitochondrial stress (MPP+) increases interaction between PHD2 and p23:Hsp90 chaperone complex.p23 inhibitor Gedunin prevents MPP+ mediated dopaminergic cell death via destabilization of PHD2‐P23‐HSP90 complex. ABSTRACT The heat shock factor 90 (hsp90) complex has long been… read more here.
Keywords: hsp90 chaperone; phd2; hsp90; stress ... See more keywords
Production of functional recombinant prolyl hydroxylase-2 enzyme in insect cells for small molecule inhibitor screening studies.
Sign Up to like & getrecommendations! Published in 2022 at "Protein expression and purification"
DOI: 10.1016/j.pep.2022.106073
Abstract: Prolyl hydroxylase-2 (PHD2) is a dioxygenase enzyme that specifically hydroxylates the hypoxia inducible factor (HIF) which then targets it for degradation in oxygenated cells. Inhibition of the activity of the PHD2 enzyme under hypoxic environmental… read more here.
Keywords: enzyme; prolyl hydroxylase; phd2; inhibitor ... See more keywords
Adipocyte deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-51718-7
Abstract: Enhancing thermogenic brown adipose tissue (BAT) function is a promising therapeutic strategy for metabolic disease. However, predominantly thermoneutral modern human living conditions deactivate BAT. We demonstrate that selective adipocyte deficiency of the oxygen-sensor HIF-prolyl hydroxylase… read more here.
Keywords: disease; oxygen; oxygen sensor; phd2 ... See more keywords
Protective Effect of Cardiomyocyte-Specific Prolyl-4-Hydroxylase 2 Inhibition on Ischemic Injury in a Mouse MI Model.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American College of Surgeons"
DOI: 10.1097/xcs.0000000000000241
Abstract: BACKGROUND Our earlier studies showed that inhibiting prolyl-4-hydroxylase enzymes (PHD-1 and PHD-3) improves angiogenesis, heart function, and limb perfusion in mouse models via stabilizing hypoxia-inducible transcription factor-alpha (HIF-1α). The present study explored the effects of… read more here.
Keywords: inhibition; prolyl hydroxylase; group; analysis ... See more keywords
Endothelial PHD2 deficiency induces apoptosis resistance and inflammation via AKT activation and AIP1 loss independent of HIF2α
Sign Up to like & getrecommendations! Published in 2024 at "American Journal of Physiology - Lung Cellular and Molecular Physiology"
DOI: 10.1101/2024.02.01.578286
Abstract: BACKGROUND In hypoxic and pseudohypoxic rodent models of pulmonary arterial hypertension (PAH), hypoxia-inducible factor (HIF) inhibition reduces disease severity. However, HIF activation alone, due to genetic alterations or use of inhibitors of prolyl hydroxylase domain… read more here.
Keywords: vascular endothelial; lung; physiology; phd2 ... See more keywords
β-Hydroxybutyrate Facilitates Postinfarction Cardiac Repair via Targeting PHD2
Sign Up to like & getrecommendations! Published in 2025 at "Circulation Research"
DOI: 10.1161/circresaha.124.325179
Abstract: BACKGROUND: Acute myocardial infarction (MI) remains one of the major causes of death worldwide, and innovative treatment strategies for MI represent a major challenge in cardiovascular medicine. Caloric restriction (CR) is the most potent nonpharmacological… read more here.
Keywords: neovascularization; cardiac repair; function; postinfarction cardiac ... See more keywords
Mechanism of hyperbaric oxygen therapy downregulating H-type angiogenesis in subchondral bone of knee osteoarthritis through the PHD2/HIF-1α pathway
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Orthopaedic Surgery and Research"
DOI: 10.1186/s13018-025-05514-8
Abstract: To explore the mechanism of hyperbaric oxygen therapy in inhibiting subchondral bone angiogenesis and delaying the progression of osteoarthritis through the PHD2/HIF-1α signaling pathway. Mice were randomly divided into three groups (control group, osteoarthritis group,… read more here.
Keywords: oxygen; oxygen therapy; phd2; hyperbaric oxygen ... See more keywords
Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14241
Abstract: Clinical studies in breast cancer suggest important associations between intratumoral hypoxia, the upregulation of epidermal growth factor receptor (EGFR or HER1), hypoxia-inducible factor 1α (HIF-1α), and reduced patient survival. However, direct molecular links between EGFR… read more here.
Keywords: phd2; egfr; breast cancer; hypoxia ... See more keywords
Prolyl hydroxylase domain enzyme PHD2 inhibits proliferation and metabolism in non-small cell lung cancer cells in HIF-dependent and HIF-independent manners
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2024.1370393
Abstract: Prolyl hydroxylase domain protein 2 (PHD2) is one of the intracellular oxygen sensors that mediates proteasomal degradation of hypoxia-inducible factor (HIF)-α via hydroxylation under normoxic conditions. Because of its canonical function in the hypoxia signaling… read more here.
Keywords: lung cancer; prolyl hydroxylase; phd2; hif ... See more keywords
Ginsenosides ameliorates high altitude-induced hypoxia injury in lung and kidney tissues by regulating PHD2/HIF-1α/EPO signaling pathway
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2024.1396231
Abstract: Background: The primary constituent of ginseng, known as ginsenosides (GS), has been scientifically demonstrated to possess anti-fatigue, anti-hypoxia, anti-inflammatory, and antioxidant properties. However, the effect and mechanisms of GS on tissue injury induced by high-altitude… read more here.
Keywords: high altitude; phd2; hypoxia; lung kidney ... See more keywords
The oxygen sensor prolyl hydroxylase domain 2 regulates the in vivo suppressive capacity of regulatory T cells
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.70555
Abstract: The oxygen sensor prolyl hydroxylase domain 2 (PHD2) plays an important role in cell hypoxia adaptation by regulating the stability of HIF proteins (HIF1α and HIF2α) in numerous cell types, including T lymphocytes. The role… read more here.
Keywords: phd2; sensor prolyl; treg; oxygen sensor ... See more keywords