Hsp90 Co‐chaperone p23 contributes to dopaminergic mitochondrial stress via stabilization of PHD2: Implications for Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2018 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2018.02.012
Abstract: HighlightsMitochondrial stress (MPP+) increases interaction between PHD2 and p23:Hsp90 chaperone complex.p23 inhibitor Gedunin prevents MPP+ mediated dopaminergic cell death via destabilization of PHD2‐P23‐HSP90 complex. ABSTRACT The heat shock factor 90 (hsp90) complex has long been… read more here.
Keywords: hsp90 chaperone; phd2; hsp90; stress ... See more keywords
Production of functional recombinant prolyl hydroxylase-2 enzyme in insect cells for small molecule inhibitor screening studies.
Sign Up to like & getrecommendations! Published in 2022 at "Protein expression and purification"
DOI: 10.1016/j.pep.2022.106073
Abstract: Prolyl hydroxylase-2 (PHD2) is a dioxygenase enzyme that specifically hydroxylates the hypoxia inducible factor (HIF) which then targets it for degradation in oxygenated cells. Inhibition of the activity of the PHD2 enzyme under hypoxic environmental… read more here.
Keywords: enzyme; prolyl hydroxylase; phd2; inhibitor ... See more keywords
Protective Effect of Cardiomyocyte-Specific Prolyl-4-Hydroxylase 2 Inhibition on Ischemic Injury in a Mouse MI Model.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American College of Surgeons"
DOI: 10.1097/xcs.0000000000000241
Abstract: BACKGROUND Our earlier studies showed that inhibiting prolyl-4-hydroxylase enzymes (PHD-1 and PHD-3) improves angiogenesis, heart function, and limb perfusion in mouse models via stabilizing hypoxia-inducible transcription factor-alpha (HIF-1α). The present study explored the effects of… read more here.
Keywords: inhibition; prolyl hydroxylase; group; analysis ... See more keywords
Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14241
Abstract: Clinical studies in breast cancer suggest important associations between intratumoral hypoxia, the upregulation of epidermal growth factor receptor (EGFR or HER1), hypoxia-inducible factor 1α (HIF-1α), and reduced patient survival. However, direct molecular links between EGFR… read more here.
Keywords: phd2; egfr; breast cancer; hypoxia ... See more keywords
The oxygen sensor prolyl hydroxylase domain 2 regulates the in vivo suppressive capacity of regulatory T cells
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.70555
Abstract: The oxygen sensor prolyl hydroxylase domain 2 (PHD2) plays an important role in cell hypoxia adaptation by regulating the stability of HIF proteins (HIF1α and HIF2α) in numerous cell types, including T lymphocytes. The role… read more here.
Keywords: phd2; sensor prolyl; treg; oxygen sensor ... See more keywords