Substituting Tyr138 in the active site loop of human phenylalanine hydroxylase affects catalysis and substrate activation
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12243
Abstract: Mammalian phenylalanine hydroxylase (PAH) is a key enzyme in l‐phenylalanine (l‐Phe) metabolism and is active as a homotetramer. Biochemical and biophysical work has demonstrated that it cycles between two states with a variably low and… read more here.
Keywords: phe; phenylalanine; phenylalanine hydroxylase; active site ... See more keywords
Balancing hydrophobicity and sequence pattern to influence self‐assembly of amphipathic peptides
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DOI: 10.1002/bip.23099
Abstract: Amphipathic peptides with alternating polar and nonpolar amino acid sequences efficiently self‐assemble into functional β‐sheet fibrils as long as the nonpolar residues have sufficient hydrophobicity. For example, the Ac‐(FKFE)2‐NH2 peptide rapidly self‐assembles into β‐sheet bilayer… read more here.
Keywords: self assembly; hydrophobicity; phe; amphipathic peptides ... See more keywords
Supramolecular Host‐Guest Interaction‐Driven Electrochemical Recognition for Pyrophosphate and Alkaline Phosphatase Analysis
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200413
Abstract: We report an electrochemical biosensor based on the supramolecular host‐guest recognition between cucurbit[7]uril (CB[7]) and L‐phenylalanine‐Cu(II) complex for pyrophosphate (PPi) and alkaline phosphatase (ALP) analysis. First, L‐Phe‐Cu(II) complex is simply synthesized by the complexation of… read more here.
Keywords: host guest; phe; supramolecular host; analysis ... See more keywords
Improved Degradation of Phenanthrene in Soil Washing Eluent by Photo‐Fenton Like Process With Citric Acid
Sign Up to like & getrecommendations! Published in 2025 at "ChemCatChem"
DOI: 10.1002/cctc.202401520
Abstract: Herein, improved degradation of phenanthrene (PHE), one of the common polycyclic aromatic hydrocarbons (PAHs), was explored in a citric acid (CA) photo‐Fenton like system under UVB irradiation. Degradation of PHE in soil washing (SW) eluent… read more here.
Keywords: photo; degradation; fenton like; soil ... See more keywords
Homochiral Asymmetric-Shaped Electron-Transporting Materials for Efficient Non-Fullerene Perovskite Solar Cells.
Sign Up to like & getrecommendations! Published in 2019 at "ChemSusChem"
DOI: 10.1002/cssc.201802234
Abstract: A design strategy is proposed for electron-transporting materials (ETMs) with homochiral asymmetric-shaped groups for highly efficient non-fullerene perovskite solar cells (PSCs). The electron transporting N,N'-bis[(R)-1-phenylethyl]naphthalene-1,4,5,8-tetracarboxylic diimide (NDI-PhE) consists of two asymmetric-shaped chiral (R)-1-phenylethyl (PhE) groups… read more here.
Keywords: fullerene; transporting materials; electron transporting; homochiral asymmetric ... See more keywords
Oral administration of phenylalanine molecularly imprinted polymer (MIP) benefits PKU mouse model
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12513
Abstract: Phenylketonuria (PKU) is a rare genetic disorder caused by a defect in the metabolism of phenylalanine (Phe). Currently, the most commonly used treatment for PKU is dietary Phe restriction. Problems associated with Phe restricted diets… read more here.
Keywords: selective molecularly; phe; molecularly imprinted; imprinted polymer ... See more keywords
The impact of phenylalanine levels during pregnancy on birth weight and later development in children born to women with phenylketonuria.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of inherited metabolic disease"
DOI: 10.1002/jimd.12600
Abstract: BACKGROUND Strict metabolic control with dietary treatment during pregnancy is essential for women with phenylketonuria (PKU), as elevated levels of phenylalanine (Phe) are toxic to the developing fetus. Maternal delay in achievement of the recommended… read more here.
Keywords: phe; development; phe levels; birth weight ... See more keywords
A phenylalanine‐free recombinant nutritional protein for the dietary management of phenylketonuria
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12719
Abstract: Phenylketonuria (PKU) is a congenital metabolic disorder that causes the systemic elevation of phenylalanine (Phe), which is neurotoxic and teratogenic. PKU is currently incurable, and management involves lifelong adherence to an unpalatable protein‐restricted diet based… read more here.
Keywords: phenylalanine free; dietary management; free recombinant; protein ... See more keywords
Long‐term safety of sapropterin in paediatric and adult individuals with phenylalanine hydroxylase deficiency: Final results of the Kuvan® Adult Maternal Paediatric European Registry multinational observational study
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12796
Abstract: Phenylketonuria is a rare inherited disorder that disrupts the metabolism of phenylalanine (Phe) to tyrosine by phenylalanine hydroxylase (PAH). Sapropterin dihydrochloride (Kuvan®) is approved for use in Europe to reduce blood Phe levels and improve… read more here.
Keywords: long term; phe; deficiency; safety ... See more keywords
Visualizing the interaction of Acanthamoeba castellanii with human retinal epithelial cells by spontaneous Raman and CARS imaging
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Raman Spectroscopy"
DOI: 10.1002/jrs.5296
Abstract: Improved understanding of the mechanism of nutrient's uptake can enable targeted manipulation of nutrient sensing pathways in medically important pathogens to a greater degree than is currently possible. In this context, we present the use… read more here.
Keywords: human retinal; castellanii; acanthamoeba castellanii; spontaneous raman ... See more keywords
Exploiting Minimalistic Backbone Engineered γ-Phenylalanine for the Formation of Supramolecular Co-Polymer.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular rapid communications"
DOI: 10.1002/marc.202200223
Abstract: Ordered supramolecular hydrogels assembled by modified aromatic amino acids often exhibit low mechanical rigidity. Aiming to stabilize the hydrogel and understand the impact of conformational freedom and hydrophobicity on the self-assembly process, we designed two… read more here.
Keywords: phe; fmoc phe; phe fmoc; backbone ... See more keywords