Substituting Tyr138 in the active site loop of human phenylalanine hydroxylase affects catalysis and substrate activation
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12243
Abstract: Mammalian phenylalanine hydroxylase (PAH) is a key enzyme in l‐phenylalanine (l‐Phe) metabolism and is active as a homotetramer. Biochemical and biophysical work has demonstrated that it cycles between two states with a variably low and… read more here.
Keywords: phe; phenylalanine; phenylalanine hydroxylase; active site ... See more keywords
Balancing hydrophobicity and sequence pattern to influence self‐assembly of amphipathic peptides
Sign Up to like & getrecommendations! Published in 2018 at "Peptide Science"
DOI: 10.1002/bip.23099
Abstract: Amphipathic peptides with alternating polar and nonpolar amino acid sequences efficiently self‐assemble into functional β‐sheet fibrils as long as the nonpolar residues have sufficient hydrophobicity. For example, the Ac‐(FKFE)2‐NH2 peptide rapidly self‐assembles into β‐sheet bilayer… read more here.
Keywords: self assembly; hydrophobicity; phe; amphipathic peptides ... See more keywords
Supramolecular Host‐Guest Interaction‐Driven Electrochemical Recognition for Pyrophosphate and Alkaline Phosphatase Analysis
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200413
Abstract: We report an electrochemical biosensor based on the supramolecular host‐guest recognition between cucurbit[7]uril (CB[7]) and L‐phenylalanine‐Cu(II) complex for pyrophosphate (PPi) and alkaline phosphatase (ALP) analysis. First, L‐Phe‐Cu(II) complex is simply synthesized by the complexation of… read more here.
Keywords: host guest; phe; supramolecular host; analysis ... See more keywords
Homochiral Asymmetric-Shaped Electron-Transporting Materials for Efficient Non-Fullerene Perovskite Solar Cells.
Sign Up to like & getrecommendations! Published in 2019 at "ChemSusChem"
DOI: 10.1002/cssc.201802234
Abstract: A design strategy is proposed for electron-transporting materials (ETMs) with homochiral asymmetric-shaped groups for highly efficient non-fullerene perovskite solar cells (PSCs). The electron transporting N,N'-bis[(R)-1-phenylethyl]naphthalene-1,4,5,8-tetracarboxylic diimide (NDI-PhE) consists of two asymmetric-shaped chiral (R)-1-phenylethyl (PhE) groups… read more here.
Keywords: fullerene; transporting materials; electron transporting; homochiral asymmetric ... See more keywords
Oral administration of phenylalanine molecularly imprinted polymer (MIP) benefits PKU mouse model
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12513
Abstract: Phenylketonuria (PKU) is a rare genetic disorder caused by a defect in the metabolism of phenylalanine (Phe). Currently, the most commonly used treatment for PKU is dietary Phe restriction. Problems associated with Phe restricted diets… read more here.
Keywords: selective molecularly; phe; molecularly imprinted; imprinted polymer ... See more keywords
The impact of phenylalanine levels during pregnancy on birth weight and later development in children born to women with phenylketonuria.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of inherited metabolic disease"
DOI: 10.1002/jimd.12600
Abstract: BACKGROUND Strict metabolic control with dietary treatment during pregnancy is essential for women with phenylketonuria (PKU), as elevated levels of phenylalanine (Phe) are toxic to the developing fetus. Maternal delay in achievement of the recommended… read more here.
Keywords: phe; development; phe levels; birth weight ... See more keywords
Visualizing the interaction of Acanthamoeba castellanii with human retinal epithelial cells by spontaneous Raman and CARS imaging
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Raman Spectroscopy"
DOI: 10.1002/jrs.5296
Abstract: Improved understanding of the mechanism of nutrient's uptake can enable targeted manipulation of nutrient sensing pathways in medically important pathogens to a greater degree than is currently possible. In this context, we present the use… read more here.
Keywords: human retinal; castellanii; acanthamoeba castellanii; spontaneous raman ... See more keywords
Exploiting Minimalistic Backbone Engineered γ-Phenylalanine for the Formation of Supramolecular Co-Polymer.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular rapid communications"
DOI: 10.1002/marc.202200223
Abstract: Ordered supramolecular hydrogels assembled by modified aromatic amino acids often exhibit low mechanical rigidity. Aiming to stabilize the hydrogel and understand the impact of conformational freedom and hydrophobicity on the self-assembly process, we designed two… read more here.
Keywords: phe; fmoc phe; phe fmoc; backbone ... See more keywords
α-Phellandrene attenuates tissular damage, oxidative stress, and TNF-α levels on acute model ifosfamide-induced hemorrhagic cystitis in mice
Sign Up to like & getrecommendations! Published in 2020 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-020-01869-3
Abstract: Hemorrhagic cystitis (HC) is the major dose-limiting adverse effect of the clinical use ifosfamide (IFOS). The incidence of this side effect can be as high as 75%. Mesna has been used to reduce the risk… read more here.
Keywords: model; ifosfamide; damage; hemorrhagic cystitis ... See more keywords
Colorimetric chiral recognition of d/l-phenylalanine based on triangular silver nanoplates
Sign Up to like & getrecommendations! Published in 2018 at "Amino Acids"
DOI: 10.1007/s00726-018-2604-9
Abstract: A new colorimetric analysis approach for chiral recognition of d- and l-forms of phenylalanine (phe) was developed based on triangular silver nanoplates (TAg-NPs). The TAg-NPs could be used as chiral colorimetric probes for d- and… read more here.
Keywords: based triangular; chiral recognition; silver nanoplates; phe ... See more keywords
Investigation of the encapsulation of metal cations (Cu2+, Zn2+, Ca2+ and Ba2+) by the dipeptide Phe–Phe using natural bond orbital theory and molecular dynamics simulation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-017-3248-5
Abstract: AbstractComplexes of the dipeptide phenylalanine–phenylalanine (Phe–Phe) with divalent metal cations (Cu2+, Zn2+, Ca2+ and Ba2+) were studied at the B3LYP and MP2 levels of theory with the basis sets 6-311++G(d,p) and 6-31 + G(d) in… read more here.
Keywords: zn2 ca2; phe phe; ca2 ba2; phe ... See more keywords