Enhancement of Z-aspartame synthesis by rational engineering of metalloprotease.
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DOI: 10.1016/j.foodchem.2018.01.108
Abstract: Metalloprotease PT121Y114S, an effective catalyst for Z-aspartame synthesis under the substrate (Z-Asp:l-Phe-OMe) molar ratio of 1:5, was obtained previously. Herein, a computational strategy combining molecular dynamics simulation of the enzyme-substrate complex with binding free energy… read more here.
Keywords: phe ome; aspartame synthesis; metalloprotease; pt121y114s ... See more keywords