Contribution of Phe112, Ser114, and Tyr115 to Drug-Binding Selectivity in the A Variant of α1-Acid Glycoprotein.
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DOI: 10.1021/acs.molpharmaceut.4c00428
Abstract: The plasma protein α1-acid glycoprotein (AGP) primarily affects the pharmacokinetics of basic drugs. There are two AGP variants in humans, A and F1*S, exhibiting distinct drug-binding selectivity. Elucidation of the drug-binding selectivity of human AGP… read more here.
Keywords: binding selectivity; acid glycoprotein; drug; phe112 ser114 ... See more keywords