Phenazine-1-Carboxylic Acid (PCA), Produced for the First Time as an Antifungal Metabolite by Truncatella angustata, a Causal Agent of Grapevine Trunk Diseases (GTDs) in Iran
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Agricultural and Food Chemistry"
DOI: 10.1021/acs.jafc.1c03877
Abstract: The phytopathogenic fungus Truncatella angustata, associated with grapevine trunk diseases (GTDs) in Iran, produces the well-known secondary metabolite isocoumumarin (+)-6-hyroxyramulosin and surprisingly also phenazine-1-carboxylic acid (PCA). PCA, identified by spectroscopic (essentially 1H NMR and ESI… read more here.
Keywords: phenazine; grapevine trunk; pca; trunk diseases ... See more keywords
Functional and Structural Analysis of Phenazine O-Methyltransferase LaPhzM from Lysobacter antibioticus OH13 and One-Pot Enzymatic Synthesis of the Antibiotic Myxin.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical biology"
DOI: 10.1021/acschembio.8b00062
Abstract: Myxin is a well-known antibiotic that had been used for decades. It belongs to the phenazine natural products that exhibit various biological activities, which are often dictated by the decorating groups on the heteroaromatic three-ring… read more here.
Keywords: myxin; laphzm; methyltransferase; phenazine ... See more keywords
Dual phenazine gene clusters enable diversification during biosynthesis
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DOI: 10.1038/s41589-019-0246-1
Abstract: Biosynthetic gene clusters (BGCs) bridging genotype and phenotype continuously evolve through gene mutations and recombinations to generate chemical diversity. Phenazine BGCs are widespread in bacteria, and the biosynthetic mechanisms of the formation of the phenazine… read more here.
Keywords: phenazine gene; phenazine; clusters enable; dual phenazine ... See more keywords
Disruption of MiaA provides insights into the regulation of phenazine biosynthesis under suboptimal growth conditions in Pseudomonas chlororaphis 30-84.
Sign Up to like & getrecommendations! Published in 2017 at "Microbiology"
DOI: 10.1099/mic.0.000409
Abstract: Many products of secondary metabolism are activated by quorum sensing (QS), yet even at cell densities sufficient for QS, their production may be repressed under suboptimal growth conditions via mechanisms that still require elucidation. For… read more here.
Keywords: growth conditions; production; suboptimal growth; phenazine ... See more keywords
Screening of natural phenazine producers for electroactivity in bioelectrochemical systems
Sign Up to like & getrecommendations! Published in 2022 at "Microbial Biotechnology"
DOI: 10.1111/1751-7915.14199
Abstract: Mediated extracellular electron transfer (EET) might be a great vehicle to connect microbial bioprocesses with electrochemical control in stirred‐tank bioreactors. However, mediated electron transfer to date is not only much less efficient but also much… read more here.
Keywords: bioelectrochemical systems; electron transfer; phenazine; natural phenazine ... See more keywords
NADH dehydrogenases are the predominant phenazine reductases in the electron transport chain of Pseudomonas aeruginosa
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Microbiology"
DOI: 10.1111/mmi.15049
Abstract: Phenazines are redox‐active secondary metabolites produced by diverse bacteria including the opportunistic pathogen Pseudomonas aeruginosa. Extracellular electron transfer via phenazines enhances anaerobic survival by serving as an electron sink for glucose catabolism. However, the specific… read more here.
Keywords: pseudomonas aeruginosa; phenazine reductase; transport chain; electron transport ... See more keywords
Synthesis, Crystal Structure and Bioactivity of Phenazine-1-carboxylic Acylhydrazone Derivatives
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DOI: 10.3390/molecules26175320
Abstract: A phenazine-1-carboxylic acid intermediate was synthesized from the reaction of aniline and 2-bromo-3-nitro-benzoic acid. It was then esterified and reacted with hydrazine hydrate to afford phenazine-1-carboxylic hydrazine. Finally, 10 new hydrazone compounds 3a–3j were obtained… read more here.
Keywords: crystal structure; structure bioactivity; phenazine; phenazine carboxylic ... See more keywords
Stability of Manganese(II)–Pyrazine, –Quinoxaline or –Phenazine Complexes and Their Potential as Carbonate Sequestration Agents
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DOI: 10.3390/molecules27051648
Abstract: Carbonate sequestration technology is a complement of CO2 sequestration technology, which might assure its long-term viability. In this work, in order to explore the interactions between Mn2+ ion with several ligands and carbonate ion, we… read more here.
Keywords: 110 log; log 110; quinoxaline; phenazine ... See more keywords
Genomic characterization of a new endophytic Streptomyces kebangsaanensis identifies biosynthetic pathway gene clusters for novel phenazine antibiotic production
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DOI: 10.7717/peerj.3738
Abstract: Background Streptomyces are well known for their capability to produce many bioactive secondary metabolites with medical and industrial importance. Here we report a novel bioactive phenazine compound, 6-((2-hydroxy-4-methoxyphenoxy) carbonyl) phenazine-1-carboxylic acid (HCPCA) extracted from Streptomyces… read more here.
Keywords: phenazine; streptomyces kebangsaanensis; kebangsaanensis; gene clusters ... See more keywords