Anti-Trichomonas vaginalis activity of 1,10-phenanthroline-5,6-dione-based metallodrugs and synergistic effect with metronidazole
Sign Up to like & getrecommendations! Published in 2018 at "Parasitology"
DOI: 10.1017/s003118201800152x
Abstract: Abstract Trichomonas vaginalis is responsible for the most common non-viral, sexually transmitted infection, human trichomoniasis, and is associated with an increased susceptibility to HIV. An escalation in resistance (2.5–10%) to the clinical drug, metronidazole (MTZ),… read more here.
Keywords: phendione clo4; vaginalis; trichomonas vaginalis; phendione ... See more keywords
1,10-Phenanthroline-5,6-Dione–Based Compounds Are Effective in Disturbing Crucial Physiological Events of Phialophora verrucosa
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DOI: 10.3389/fmicb.2017.00076
Abstract: Phialophora verrucosa is a dematiaceous fungus able to cause chromoblastomycosis, phaeohyphomycosis and mycetoma. All these fungal diseases are extremely difficult to treat and often refractory to the current therapeutic approaches. Therefore, there is an urgent… read more here.
Keywords: phendione phendione; phenanthroline dione; physiological events; crucial physiological ... See more keywords
The Anti-Leishmania amazonensis and Anti-Leishmania chagasi Action of Copper(II) and Silver(I) 1,10-Phenanthroline-5,6-dione Coordination Compounds
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DOI: 10.3390/pathogens12010070
Abstract: Leishmaniasis is a neglected disease caused by protozoa belonging to the Leishmania genus. Notably, the search for new, promising and potent anti-Leishmania compounds remains a major goal due to the inefficacy of the available drugs… read more here.
Keywords: anti leishmania; phendione; phenanthroline dione; chagasi ... See more keywords
Peptidases Are Potential Targets of Copper(II)-1,10-Phenanthroline-5,6-dione Complex, a Promising and Potent New Drug against Trichomonas vaginalis
Sign Up to like & getrecommendations! Published in 2023 at "Pathogens"
DOI: 10.3390/pathogens12050745
Abstract: Trichomonas vaginalis is responsible for 156 million new cases per year worldwide. When present asymptomatically, the parasite can lead to serious complications, such as development of cervical and prostate cancer. As infection increases the acquisition… read more here.
Keywords: potential targets; vaginalis peptidases; peptidases potential; phendione ... See more keywords