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Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22491
Abstract: A previous study reported that compound 5A, a caffeic acid phenethyl ester (CAPE) analog, exhibited obvious neuroprotective activity, in particular, compound 5A possessed higher stability and membrane permeability than CAPE. CAPE displays antitumour function; therefore,…
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Keywords:
caffeic acid;
phenethyl ester;
proliferation;
analog ... See more keywords
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Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7707
Abstract: Caffeic acid phenethyl ester (CAPE), a main active component of propolis and a flavonoid, is one of the natural products that has attracted attention in recent years. CAPE, which has many properties such as anti‐cancer,…
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Keywords:
acid phenethyl;
phenethyl ester;
cape;
caffeic acid ... See more keywords
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Published in 2021 at "Naunyn-Schmiedeberg's archives of pharmacology"
DOI: 10.1007/s00210-021-02054-w
Abstract: The past decades have seen a growing interest in natural products. Caffeic acid phenethyl ester (CAPE), a flavonoid isolated from honeybee propolis, has shown multiple pharmacological potentials, including anti-cancer, anti-inflammatory, antioxidant, antibacterial, antifungal, and protective…
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Keywords:
caffeic acid;
recent progresses;
progresses pharmacological;
phenethyl ester ... See more keywords
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Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.11.066
Abstract: Myeloid differentiation protein 2 (MD2) is an essential molecule which recognizes lipopolysaccharide (LPS), leading to initiation of inflammation through the activation of Toll-like receptor 4 (TLR4) signaling. Caffeic acid phenethyl ester (CAPE) from propolis of…
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Keywords:
caffeic acid;
differentiation protein;
phenethyl ester;
myeloid differentiation ... See more keywords
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Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.05.013
Abstract: ABSTRACT Caffeic acid phenethyl ester (CAPE) possesses a set of valuable biological properties: antioxidant, antibacterial, antitumor, anti‐inflammatory, antiviral, etc. However, CAPE is poorly soluble in aqueous environment which is limiting its possible therapeutic applications. In…
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Keywords:
caffeic acid;
phenethyl ester;
poly hydroxybutyrate;
cape ... See more keywords
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Published in 2021 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c00822
Abstract: Bioglycosylation is an efficient strategy to improve biological activities and physicochemical properties of natural compounds to develop structural modifications of drugs. In this study, an N555 residue was identified as a candidate for site-directed mutagenesis…
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Keywords:
caffeic acid;
acceptor substrate;
phenethyl ester;
acid phenethyl ... See more keywords
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Published in 2019 at "International Journal of Oral Science"
DOI: 10.1038/s41368-018-0039-5
Abstract: Periodontal disease is associated with chronic oxidative stress and inflammation. Caffeic acid phenethyl ester (CAPE), which is a potent inducer of heme oxygenase 1 (HO1), is a central active component of propolis, and the application of…
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Keywords:
caffeic acid;
phenethyl ester;
inflammation;
cape ... See more keywords
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Published in 2017 at "Pathogens and Global Health"
DOI: 10.1080/20477724.2017.1380946
Abstract: Abstract Lymphatic filariasis (LF) is a vector borne disease caused by parasitic worms such as Wuchereria bancrofti, Brugia malayi and B. timori, which are transmitted by mosquitoes. Current therapeutics to treat LF are mainly microfilarcidal,…
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Keywords:
caffeic acid;
phenethyl ester;
pahangi;
cape ... See more keywords
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Published in 2019 at "BioMed Research International"
DOI: 10.1155/2019/5390720
Abstract: Caffeic acid phenethyl ester (CAPE), the main component of propolis, has various biological activities including anti-inflammatory effect and wound healing promotion. Odontoblasts located in the outermost layer of dental pulp play crucial roles such as…
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Keywords:
caffeic acid;
production;
phenethyl ester;
expression ... See more keywords
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Published in 2022 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2022.5190
Abstract: Osteoarthritis (OA) is the most common degenerative disease affecting the joints, and inflammation appears to play a critical role in the initiation and progression of OA. Caffeic acid phenethyl ester (CAPE), a natural flavonoid compound,…
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Keywords:
acid phenethyl;
signaling pathway;
progression;
cape ... See more keywords