Discovery and Biosynthesis of Antimicrobial Phenethylamine Alkaloids from the Marine Flavobacterium Tenacibaculum discolor sv11.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.1c01173
Abstract: The bacterial genus Tenacibaculum has been associated with various ecological roles in marine environments. Members of this genus can act, for example, as pathogens, predators, or episymbionts. However, natural products produced by these bacteria are… read more here.
Keywords: phenethylamine; tenacibaculum; tenacibaculum discolor; discolor sv11 ... See more keywords
Investigation of the 2,5-dimethoxy motif in phenethylamine Serotonin 2A receptor agonists.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00129
Abstract: The 2,5-dimethoxyphenethylamine (2, 5-PEA) scaffold is recognized as a motif conferring potent agonist activity at the seroto-nin 2A receptor (5-HT2AR). The 2,5-dimethoxy motif is present in several classical phenethylamine psychedelics such as mesca-line, TMA-2, DOM,… read more here.
Keywords: phenethylamine; ht2ar; investigation dimethoxy; dimethoxy motif ... See more keywords
2-Heteroarylethylamines in medicinal chemistry: a review of 2-phenethylamine satellite chemical space
Sign Up to like & getrecommendations! Published in 2024 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.20.163
Abstract: The concept of bioisostere replacement is of paramount importance in medicinal chemistry, as it can be employed as a rational to expand bioactive chemical space to tackle lead optimization issues like lack of potency, efficacy,… read more here.
Keywords: chemistry; chemical space; review; phenethylamine ... See more keywords