Phenformin increases early hematopoietic progenitors in the Jak2V617F murine model
Sign Up to like & getrecommendations! Published in 2022 at "Investigational New Drugs"
DOI: 10.1007/s10637-022-01212-y
Abstract: Background. Myeloproliferative neoplasms (MPN) are disorders characterized by an alteration at the hematopoietic stem cell (HSC) level, where the JAK2 mutation is the most common genetic alteration found in classic MPN (polycythemia vera, essential thrombocythemia,… read more here.
Keywords: jak2; jak2 v617f; phenformin; early hematopoietic ... See more keywords
Treatment of Pancreatic Cancer Patient–Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin
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DOI: 10.1158/1078-0432.ccr-17-1115
Abstract: Purpose: To identify effective metabolic inhibitors to suppress the aggressive growth of pancreatic ductal adenocarcinoma (PDAC), we explored the in vivo antitumor efficacy of metabolic inhibitors, as single agents, in a panel of patient-derived PDAC… read more here.
Keywords: inhibitor; metabolic inhibitors; treatment; phenformin ... See more keywords
Phenformin inhibits growth and epithelial-mesenchymal transition of ErbB2-overexpressing breast cancer cells through targeting the IGF1R pathway.
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DOI: 10.18632/oncotarget.19466
Abstract: Reports suggest that metformin, a popular anti-diabetes drug, prevents breast cancer through various systemic effects, including insulin-like growth factor receptor (IGFR) regulation. Although the anti-cancer properties of metformin have been well-studied, reports on a more… read more here.
Keywords: overexpressing breast; erbb2 overexpressing; breast cancer; phenformin ... See more keywords
Phenformin inhibits cell proliferation and induces cell apoptosis and autophagy in cholangiocarcinoma.
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DOI: 10.3892/mmr.2018.8573
Abstract: Cholangiocarcinoma (CCA) is an aggressive malignant tumor and the prognosis of patients with advanced stage disease remains poor. Therefore, the identification of novel treatment agents for CCA is required. In the present study, the biological… read more here.
Keywords: cell proliferation; cell apoptosis; phenformin; cell ... See more keywords