A computational study on phenibut lactamization mechanism and the pH effects on the process
Sign Up to like & getrecommendations! Published in 2020 at "Theoretical Chemistry Accounts"
DOI: 10.1007/s00214-020-02617-9
Abstract: The current work investigates the lactamization reaction of neuropsychotropic medicine phenibut to higher toxicity phenibut-lactam. The reaction is considered as an intramolecular cyclization which finally leads to generation of phenibut-lactam component. Herein, we considered three… read more here.
Keywords: kcal mol; study phenibut; computational study; reaction ... See more keywords
F-phenibut (β-(4-Fluorophenyl)-GABA), a potent GABAB receptor agonist, activates an outward-rectifying K+ current and suppresses the generation of action potentials in mouse cerebellar Purkinje cells.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173437
Abstract: The GABA analog phenibut (β-Phenyl-GABA) is a GABAB receptor agonist that has been licensed for various uses in Russia. Phenibut is also available as a dietary supplement from online vendors worldwide, and previous studies have… read more here.
Keywords: gabab; agonist; rectifying current; phenibut ... See more keywords
Case Report of Physiologic Phenibut Dependence Treated With a Phenobarbital Taper in a Patient Being Treated With Buprenorphine.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Addiction Medicine"
DOI: 10.1097/adm.0000000000000303
Abstract: : This case report describes the development of dependence to phenibut, a gamma-aminobutyric acid-receptor type B agonist, in a patient concurrently being treated with buprenorphine. The patient experienced withdrawal symptoms which were successfully treated with… read more here.
Keywords: patient; treated buprenorphine; phenibut; case report ... See more keywords
Clinical Presentations and Treatment of Phenibut Toxicity and Withdrawal: A Systematic Literature Review.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of addiction medicine"
DOI: 10.1097/adm.0000000000001141
Abstract: OBJECTIVES This systematic review aimed to identify published articles that evaluated all phenibut toxicity and withdrawal cases to understand better their clinical presentations and treatments. METHODS A comprehensive literature search was conducted using Medline (Ovid),… read more here.
Keywords: phenibut; treatment; phenibut toxicity; toxicity withdrawal ... See more keywords