Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads.
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DOI: 10.1021/acs.bioconjchem.7b00576
Abstract: The valine-citrulline (Val-Cit) dipeptide and p-aminobenzyl (PAB) spacer have been commonly used as a cleavable self-immolating linker in ADC design including in the clinically approved ADC, brentuximab vedotin (Adcetris). When the same linker was used… read more here.
Keywords: potency; cell killing; immolation; killing activity ... See more keywords
Effect of Silica Sodalite Loading on SOD/PSF Membranes during Treatment of Phenol-Containing Wastewater
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DOI: 10.3390/membranes12080800
Abstract: In this study, silica sodalite (SSOD) was prepared via topotactic conversion and different silica sodalite loadings were infused into the polysulfone (PSF) for application in phenol-containing water treatment. The composite membranes were fabricated through the… read more here.
Keywords: containing water; silica sodalite; phenol containing; treatment ... See more keywords