Cascade Aryne Aminoarylation for Biaryl Phenol Synthesis
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DOI: 10.1021/acs.orglett.4c00624
Abstract: We describe a transition metal-free approach to hindered 3-amino-2-aryl phenols through a cascade nucleophilic addition / Smiles–Truce rearrangement of a functionalized Kobayashi aryne precursor. Under anionic conditions, secondary alkyl amines add to the aryne intermediate… read more here.
Keywords: aryne aminoarylation; cascade aryne; phenol synthesis; biaryl phenol ... See more keywords