A phenome‐wide investigation of risk factors for severe COVID‐19
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28264
Abstract: With the continued spread of COVID‐19 globally, it is crucial to identify the potential risk or protective factors associated with COVID‐19. Here, we performed genetic correlation analysis and Mendelian randomization analysis to examine genetic relationships… read more here.
Keywords: severe covid; phenome wide; risk factors; risk ... See more keywords
Health effects of high serum calcium levels: Updated phenome-wide Mendelian randomisation investigation and review of Mendelian randomisation studies
Sign Up to like & getrecommendations! Published in 2022 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2022.103865
Abstract: Summary Background Calcium plays a role in a wide range of biological functions. Here we conducted a phenome-wide Mendelian randomisation (MR-PheWAS) analysis and a systematic review for MR studies to comprehensively investigate the health effects… read more here.
Keywords: review; phenome wide; calcium; mendelian randomisation ... See more keywords
Phenome-wide screening for traits causally associated with the risk of coronary artery disease
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Human Genetics"
DOI: 10.1038/s10038-019-0716-z
Abstract: Using two independent approaches, Mendelian randomization and Polygenic risk score in a sample of 6194 CAD cases and 4287 controls of European ancestry, we did a comprehensive phenome-wide search (PheWAS) for traits that causally associated… read more here.
Keywords: phenome wide; risk; causally associated; cad ... See more keywords
Searching for causal relationships of glioma: a phenome-wide Mendelian randomisation study
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Cancer"
DOI: 10.1038/s41416-020-01083-1
Abstract: Background The aetiology of glioma is poorly understood. Summary data from genome-wide association studies (GWAS) can be used in a Mendelian randomisation (MR) phenome-wide association study (PheWAS) to search for glioma risk factors. Methods We… read more here.
Keywords: phenome wide; glioma; study; mendelian randomisation ... See more keywords
Rare variants in drug target genes contributing to complex diseases, phenome-wide
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-22834-4
Abstract: The DrugBank database consists of ~800 genes that are well characterized drug targets. This list of genes is a useful resource for association testing. For example, loss of function (LOF) genetic variation has the potential… read more here.
Keywords: phenome wide; variants drug; variation; target genes ... See more keywords
DeepPheWAS: an R package for phenotype generation and association analysis for phenome-wide association studies
Sign Up to like & getrecommendations! Published in 2023 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btad073
Abstract: Abstract Summary DeepPheWAS is an R package for phenome-wide association studies that creates clinically curated composite phenotypes and integrates quantitative phenotypes from primary care data, longitudinal trajectories of quantitative measures, disease progression and drug response… read more here.
Keywords: deepphewas package; wide association; phenome wide; analysis ... See more keywords
NETMAGE: A human disease phenotype map generator for the network-based visualization of phenome-wide association study results
Sign Up to like & getrecommendations! Published in 2022 at "GigaScience"
DOI: 10.1093/gigascience/giac002
Abstract: Abstract Background Disease complications, the onset of secondary phenotypes given a primary condition, can exacerbate the long-term severity of outcomes. However, the exact cause of many of these cross-phenotype associations is still unknown. One potential… read more here.
Keywords: network; phenotype; disease; wide association ... See more keywords
Gene-SCOUT: identifying genes with similar continuous trait fingerprints from phenome-wide association analyses
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac274
Abstract: Abstract Large-scale phenome-wide association studies performed using densely-phenotyped cohorts such as the UK Biobank (UKB), reveal many statistically robust gene-phenotype relationships for both clinical and continuous traits. Here, we present Gene-SCOUT, a tool used to… read more here.
Keywords: gene scout; trait; wide association; phenome wide ... See more keywords
Phenome-wide Association Analysis of Substance Use Disorders in a Deeply Phenotyped Sample
Sign Up to like & getrecommendations! Published in 2022 at "Biological Psychiatry"
DOI: 10.1101/2022.02.09.22270737
Abstract: Background: Substance use disorders (SUDs) are associated with a variety of co-occurring psychiatric disorders and other SUDs, which partly reflects genetic pleiotropy. Polygenic risk scores (PRS) and phenome-wide association studies (PheWAS) are useful in evaluating… read more here.
Keywords: substance; substance use; phenome wide; deeply phenotyped ... See more keywords
Phenome-wide Mendelian randomisation analysis identifies causal factors for age-related macular degeneration
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.08.24.22279172
Abstract: Introduction: Age-related macular degeneration (AMD) is the leading cause of blindness in the industrialised world and is projected to affect 288 million people worldwide by 2040. Aiming to identify causal factors for this common disorder,… read more here.
Keywords: related macular; causal factors; age related; macular degeneration ... See more keywords
Phenome-wide genetic correlation analysis and genetically-informed causal inference of amyotrophic lateral sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Human genetics"
DOI: 10.1101/2022.09.27.22280414
Abstract: Leveraging genome-wide association statistics generated from a large study of amyotrophic lateral sclerosis (ALS; 29,612 cases and 122,656 controls) and UK Biobank (UKB; 4,024 phenotypes, up to 361,194 participants), we conducted a phenome-wide genetic correlation… read more here.
Keywords: phenome wide; lateral sclerosis; analysis; causal ... See more keywords