Articles with "phenothiazine antipsychotics" as a keyword



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Continuous-Flow Synthesis of Phenothiazine Antipsychotics: A Feasibility Study

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Published in 2019 at "European Journal of Organic Chemistry"

DOI: 10.1002/ejoc.201801689

Abstract: The continuous flow synthesis of a model phenothiazine antipsychotic is presented herein, using 3-chloropropionyl chloride as a central building block. The basic phenothiazine-derived scaffold is (atom)-efficiently and mildly synthesized with the aim to present continuous… read more here.

Keywords: flow synthesis; phenothiazine; continuous flow; phenothiazine antipsychotics ... See more keywords
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Repurposing Antidepressants and Phenothiazine Antipsychotics as Efflux Pump Inhibitors in Cancer and Infectious Diseases

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Published in 2023 at "Antibiotics"

DOI: 10.3390/antibiotics12010137

Abstract: Multidrug resistance (MDR) is a major obstacle in the therapy of infectious diseases and cancer. One of the major mechanisms of MDR is the overexpression of efflux pumps (EPs) that are responsible for extruding antimicrobial… read more here.

Keywords: infectious diseases; phenothiazine antipsychotics; development; repurposing antidepressants ... See more keywords