The genomic and biological complexity of mixed phenotype acute leukemia
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DOI: 10.1080/10408363.2020.1829537
Abstract: Abstract Mixed phenotype acute leukemia (MPAL) is a heterogeneous group of leukemias that are defined immunophenotypically by antigen expression on blasts of both myeloid and lymphoid lineage. With the exception of BCR-ABL positive and KMT2A… read more here.
Keywords: phenotype acute; acute leukemia; leukemia; mixed phenotype ... See more keywords
Adult mixed phenotype acute leukemia (MPAL): B/myeloid MPALisoMPO is distinct from other MPAL subtypes
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DOI: 10.1111/ijlh.13988
Abstract: Myeloperoxidase (MPO) is considered a specific marker of myeloid/non‐monocytic lineage in the diagnosis of mixed phenotype acute leukemia (MPAL). However, the clinical significance of isolated dim MPO expression in otherwise typical B lymphoblastic leukemia (B‐ALL;… read more here.
Keywords: mixed phenotype; phenotype acute; leukemia; acute leukemia ... See more keywords
The Clinical Tumor Lysis Syndrome in a Patient with Mixed Phenotype Acute Leukemia Undergoing Induction with Venetoclax and Azacitidine: A Case Report
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DOI: 10.1159/000524182
Abstract: A combination of azacitidine and venetoclax (AZA-VEN) has been approved for the treatment of adult treatment-naïve acute myeloid leukemia (AML) patients, ineligible for intensive chemotherapy. The protocol may also constitute an alternative for the treatment… read more here.
Keywords: mixed phenotype; phenotype acute; leukemia; patient ... See more keywords
Recognizing Minor Leukemic Populations with Monocytic Features in Mixed-Phenotype Acute Leukemia by Flow Cell Sorting Followed by Cytogenetic and Molecular Studies: Report of Five Exemplary Cases
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DOI: 10.3390/ijms24065260
Abstract: Mixed-phenotype acute leukemia (MPAL), a rare and heterogeneous category of acute leukemia, is characterized by cross-lineage antigen expression. Leukemic blasts in MPAL can be represented either by one population with multiple markers of different lineages… read more here.
Keywords: mixed phenotype; leukemic populations; acute leukemia; phenotype acute ... See more keywords