LAUSR

Literature-based prediction of novel drug indications considering relationships between entities.

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0 Published in 2017 at "Molecular bioSystems"

DOI: 10.1039/c7mb00020k

Abstract: There have been many attempts to identify and develop new uses for existing drugs, which is known as drug repositioning. Among these efforts, text mining is an effective means of discovering novel knowledge from a… read more here.

Keywords: phenotype; phenotype associations; drug phenotype; drug repositioning ... See more keywords

Statistical Analysis of Multiple Phenotypes in Genetic Epidemiologic Studies: From Cross-Phenotype Associations to Pleiotropy

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0 Published in 2018 at "American Journal of Epidemiology"

DOI: 10.1093/aje/kwx296

Abstract: In the context of genetics, pleiotropy refers to the phenomenon in which a single genetic locus affects more than 1 trait or disease. Genetic epidemiologic studies have identified loci associated with multiple phenotypes, and these… read more here.

Keywords: phenotype associations; analysis; epidemiologic studies; cross phenotype ... See more keywords

PheLiGe: an interactive database of billions of human genotype–phenotype associations

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0 Published in 2021 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkaa1086

Abstract: Abstract Genome-wide association studies have provided a vast array of publicly available SNP × phenotype association results. However, they are often in disparate repositories and formats, making downstream analyses difficult and time consuming. PheLiGe (https://phelige.com)… read more here.

Keywords: phenotype; phenotype associations; genotype phenotype; association ... See more keywords

Targeted next-generation sequencing detects novel gene–phenotype associations and expands the mutational spectrum in cardiomyopathies

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0 Published in 2017 at "PLoS ONE"

DOI: 10.1371/journal.pone.0181842

Abstract: Cardiomyopathies are a heterogeneous group of primary diseases of the myocardium, including hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and arrhythmogenic right ventricular cardiomyopathy (ARVC), with higher morbidity and mortality. These diseases are genetically diverse and… read more here.

Keywords: targeted next; phenotype associations; gene phenotype; gene ... See more keywords