ScaffComb: A Phenotype-Based Framework for Drug Combination Virtual Screening in Large-Scale Chemical Datasets.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced science"
DOI: 10.1002/advs.202102092
Abstract: Combinational therapy is used for a long time in cancer treatment to overcome drug resistance related to monotherapy. Increased pharmacological data and the rapid development of deep learning methods have enabled the construction of models… read more here.
Keywords: large scale; virtual screening; drug; phenotype based ... See more keywords
Cholinesterase Inhibitory Arisugacins L-Q from a Penicillium sp. Isolate Obtained through a Citizen Science Initiative and Their Activities in a Phenotype-Based Zebrafish Assay.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.9b00563
Abstract: Phenotype-based screening of a fungal extract library yielded an active sample from a Penicillium sp. isolate that impaired zebrafish motility. Bioassay-guided purification led to the identification of 14 meroterpenoids including six new metabolites, arisugacins L-Q… read more here.
Keywords: phenotype based; inhibitory arisugacins; penicillium isolate; cholinesterase inhibitory ... See more keywords
Phenotype-Based Threat Assessment
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2112886119
Abstract: Significance Assessing the threat posed by bacterial samples is fundamentally important to safeguarding human health. Whole-genome sequence analysis of bacteria provides a route to achieving this goal. However, this approach is fundamentally constrained by the… read more here.
Keywords: phenotype based; threat; genome; threat assessment ... See more keywords
Phenotype-based screening of selected mangrove methanolic crude extracts with anti-melanogenic activity using zebrafish (Danio rerio) as a model
Sign Up to like & getrecommendations! Published in 2017 at "Scienceasia"
DOI: 10.2306/scienceasia1513-1874.2017.43.163
Abstract: Novel skin hypopigmenting agents are important due to the unwanted side effects of existing therapies and treatments. In this study, the melanogenic effects of crude extracts of selected mangroves, namely, Avicennia marina, Excoecaria agallocha, Rhizophora… read more here.
Keywords: using zebrafish; phenotype based; model; crude extracts ... See more keywords
Phenotype-based drug screening: An in vivo strategy to classify and identify the chemical compounds modulating zebrafish M-cell regeneration
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.984461
Abstract: Several disease-modulatory FDA-approved drugs are being used in patients with neurodegenerative diseases. However, information on their toxicity-related profiles is very limited. Therefore, measurement of drug toxicity is essential to increase the knowledge of their side… read more here.
Keywords: phenotype based; regeneration; cell regeneration; based drug ... See more keywords