Information-theoretic characterization of the complete genotype-phenotype map of a complex pre-biotic world
Sign Up to like & getrecommendations! Published in 2021 at "Physics of life reviews"
DOI: 10.1016/j.plrev.2021.06.001
Abstract: How information is encoded in bio-molecular sequences is difficult to quantify since such an analysis usually requires sampling an exponentially large genetic space. Here we show how information theory reveals both robust and compressed encodings… read more here.
Keywords: information; phenotype map; complete genotype; genotype phenotype ... See more keywords
Adding levels of complexity enhances robustness and evolvability in a multilevel genotype–phenotype map
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DOI: 10.1098/rsif.2017.0516
Abstract: Robustness and evolvability are the main properties that account for the stability and accessibility of phenotypes. They have been studied in a number of computational genotype–phenotype maps. In this paper, we study a metabolic genotype–phenotype… read more here.
Keywords: robustness evolvability; genotype; phenotype map; genotype phenotype ... See more keywords
Populations of genetic circuits are unable to find the fittest solution in a multilevel genotype–phenotype map
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DOI: 10.1098/rsif.2019.0843
Abstract: The evolution of gene regulatory networks (GRNs) is of great relevance for both evolutionary and synthetic biology. Understanding the relationship between GRN structure and its function can allow us to understand the selective pressures that… read more here.
Keywords: phenotype; genotype phenotype; genotype; multilevel genotype ... See more keywords
Fast free-energy-based neutral set size estimates for the RNA genotype–phenotype map
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Royal Society Interface"
DOI: 10.1098/rsif.2022.0072
Abstract: The genotype–phenotype (GP) map of RNA secondary structure links each RNA sequence to its corresponding secondary structure. Previous research has shown that the large-scale structural properties of GP maps, such as the size of neutral… read more here.
Keywords: set size; neutral set; energy; genotype phenotype ... See more keywords