Novel Polyamine–Naphthalene Diimide Conjugates Targeting Histone Deacetylases and DNA for Cancer Phenotype Reprogramming
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DOI: 10.1021/acsmedchemlett.7b00289
Abstract: A series of hybrid compounds was designed to target histone deacetylases and ds-/G-quadruplex DNAs by merging structural features deriving from Scriptaid and compound 1. Compound 6 binds different DNA arrangements, inhibits HDACs both in vitro… read more here.
Keywords: cancer; novel polyamine; histone deacetylases; phenotype reprogramming ... See more keywords