Assessing gene-environment interaction effects of FTO, MC4R and lifestyle factors on obesity using an extreme phenotype sampling design: Results from the HUNT study
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DOI: 10.1371/journal.pone.0175071
Abstract: Background Our aim was to assess the influence of age, gender and lifestyle factors on the effect of the obesity-promoting alleles of FTO and MCR4. Methods The HUNT study comprises health information on the population… read more here.
Keywords: phenotype; lifestyle factors; hunt study; phenotype sampling ... See more keywords
A Cautionary Note on the Effects of Population Stratification Under an Extreme Phenotype Sampling Design
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DOI: 10.3389/fgene.2019.00398
Abstract: Extreme phenotype sampling (EPS) is a popular study design used to reduce genotyping or sequencing costs. Assuming continuous phenotype data are available on a large cohort, EPS involves genotyping or sequencing only those individuals with… read more here.
Keywords: phenotype; phenotype sampling; extreme phenotype; population stratification ... See more keywords