Detection of phenotype‐specific therapeutic vulnerabilities in breast cells using a CRISPR loss‐of‐function screen
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12951
Abstract: Cellular phenotype plasticity between the epithelial and mesenchymal states has been linked to metastasis and heterogeneous responses to cancer therapy, and remains a challenge for the treatment of triple‐negative breast cancer (TNBC). Here, we used… read more here.
Keywords: phenotype; loss function; function screen; phenotype specific ... See more keywords
Dosha phenotype specific Ayurveda intervention ameliorates asthma symptoms through cytokine modulations: Results of whole system clinical trial.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2016.07.071
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Over the past few decades, there have been significant scientific advances leading to improved understanding of asthma as a disease and treatment providing immediate relief. However, prevention of recurrent attacks, exacerbations and disease… read more here.
Keywords: intervention; clinical trial; treatment; phenotype specific ... See more keywords
Convergent shifts in host-associated microbial communities across environmentally elicited phenotypes
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03383-w
Abstract: Morphological plasticity is a genotype-by-environment interaction that enables organisms to increase fitness across varying environments. Symbioses with diverse microbiota may aid in acclimating to this variation, but whether the associated bacteria community is phenotype specific… read more here.
Keywords: convergent shifts; host; phenotype specific; morphological plasticity ... See more keywords
PROSE: phenotype-specific network signatures from individual proteomic samples
Sign Up to like & getrecommendations! Published in 2023 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbad075
Abstract: Proteomic studies characterize the protein composition of complex biological samples. Despite recent advancements in mass spectrometry instrumentation and computational tools, low proteome coverage and interpretability remains a challenge. To address this, we developed Proteome Support… read more here.
Keywords: network; prose phenotype; phenotype specific; network signatures ... See more keywords
IntAPT: integrated assembly of phenotype-specific transcripts from multiple RNA-seq profiles
Sign Up to like & getrecommendations! Published in 2021 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btaa852
Abstract: MOTIVATION High-throughput RNA sequencing has revolutionized the scope and depth of transcriptome analysis. Accurate reconstruction of a phenotype-specific transcriptome is challenging due to the noise and variability of RNA-seq data. This requires computational identification of… read more here.
Keywords: integrated assembly; assembly phenotype; phenotype specific; transcripts multiple ... See more keywords
Phenotype‐specific signatures of systems‐level gut microbiome associated with childhood airway allergies
Sign Up to like & getrecommendations! Published in 2023 at "Pediatric Allergy and Immunology"
DOI: 10.1111/pai.13905
Abstract: Perturbation of gut symbiosis has been linked to childhood allergic diseases. However, the underlying host–microbe interaction connected with specific phenotypes is poorly understood. read more here.
Keywords: level gut; phenotype specific; signatures systems; childhood ... See more keywords