Not all phenotypes are created equal: covariates of success in e-phenotype specification
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Medical Informatics Association : JAMIA"
DOI: 10.1093/jamia/ocac157
Abstract: Abstract Background Electronic (e)-phenotype specification by noninformaticist investigators remains a challenge. Although validation of each patient returned by e-phenotype could ensure accuracy of cohort representation, this approach is not practical. Understanding the factors leading to… read more here.
Keywords: phenotype specification; phenotype; validation; created equal ... See more keywords
Timing of MeCP2 Expression Determines Midbrain Dopamine Neuron Phenotype Specification.
Sign Up to like & getrecommendations! Published in 2022 at "Stem cells"
DOI: 10.1093/stmcls/sxac061
Abstract: Midbrain dopamine (DA) neurons are associated with locomotor and psychiatric disorders. DA phenotype is specified in ancestral neural precursor cells (NPCs) and maintained throughout neuronal differentiation. Here we show that endogenous expression of MeCP2 coincides… read more here.
Keywords: phenotype specification; methylation; mecp2 expression; expression ... See more keywords