Role of ROS-TRPM7-ERK1/2 axis in high concentration glucose-mediated proliferation and phenotype switching of rat aortic vascular smooth muscle cells.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.10.122
Abstract: This study investigated the change of transient receptor potential cation channel subfamily M member 7 (TRPM7) expression in rat aortic vascular smooth muscle cells (RAoSMCs) treated with a high concentration of d-glucose (HG) and its… read more here.
Keywords: phenotype; high concentration; concentration glucose; phenotype switching ... See more keywords
Molecular regulation of vascular smooth muscle cell phenotype switching by trophoblast cells at the maternal-fetal interface.
Sign Up to like & getrecommendations! Published in 2020 at "Placenta"
DOI: 10.1016/j.placenta.2020.02.017
Abstract: INTRODUCTION Establishment of hemochorial placenta is associated with development and remodelling of uterine vasculature at the maternal fetal interface. This results in calibration of high resistance uterine arteries to flaccid low resistance vessels resulting in… read more here.
Keywords: trophoblast cells; vascular smooth; phenotype switching; smooth muscle ... See more keywords
Targeting fibroblast phenotype switching in cardiac remodelling as a promising antifibrotic strategy.
Sign Up to like & getrecommendations! Published in 2024 at "European heart journal"
DOI: 10.1093/eurheartj/ehae722
Abstract: Myocardial fibrosis, a common feature of heart disease, remains an unsolved clinical challenge. Fibrosis resolution requires activation of cardiac fibroblasts exhibiting context-dependent beneficial and detrimental dichotomy. Here, we explored the hypothesis of fibroblast reversible transition… read more here.
Keywords: cardiac remodelling; phenotype switching; fibrosis; fibroblast phenotype ... See more keywords
Metabolomics analysis of acute lung injury induced by aortic dissection in mice
Sign Up to like & getrecommendations! Published in 2025 at "Annals of Medicine and Surgery"
DOI: 10.1097/ms9.0000000000002885
Abstract: Thoracic aortic aneurysm/dissection (TAA/D) is a complicated vascular disorder with galloping development and high mortality. Phenotype switching plays an important role in the pathological process of TAA/D. Previous studies indicated the potential correlation between the… read more here.
Keywords: phenotype switching; analysis; dissection; expression ... See more keywords
LncRNA PSR Regulates Vascular Remodeling Through Encoding a Novel Protein Arteridin
Sign Up to like & getrecommendations! Published in 2022 at "Circulation Research"
DOI: 10.1161/circresaha.122.321080
Abstract: Rationale: Vascular smooth muscle cells (VSMCs) phenotype switch from contractile to proliferative phenotype is a pathological hallmark in various cardiovascular diseases. Recently, a subset of long noncoding RNAs was identified to produce functional polypeptides. However,… read more here.
Keywords: vsmc; phenotype switching; vascular remodeling; psr ... See more keywords
Connecting Metabolic Rewiring With Phenotype Switching in Melanoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.930250
Abstract: Melanoma is a complex and aggressive cancer type that contains different cell subpopulations displaying distinct phenotypes within the same tumor. Metabolic reprogramming, a hallmark of cell transformation, is essential for melanoma cells to adopt different… read more here.
Keywords: cell; melanoma; phenotype switching; rewiring phenotype ... See more keywords
Methyltransferase like 3-mediated N6-methylatidin methylation inhibits vascular smooth muscle cells phenotype switching via promoting phosphatidylinositol 3-kinase mRNA decay
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.913039
Abstract: N6-methylatidine (m6A) is involved in post-transcriptional metabolism and a variety of pathological processes. However, little is known about the role of m6A in vascular proliferative diseases, particularly in vascular smooth muscle cells (VSMCs) phenotype switching-induced… read more here.
Keywords: muscle cells; phenotype switching; vascular smooth; m6a ... See more keywords
EMT-Inducing Transcription Factors, Drivers of Melanoma Phenotype Switching, and Resistance to Treatment
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12082154
Abstract: Transcription factors, extensively described for their role in epithelial–mesenchymal transition (EMT-TFs) in epithelial cells, also display essential functions in the melanocyte lineage. Recent evidence has shown specific expression patterns and functions of these EMT-TFs in… read more here.
Keywords: transcription factors; phenotype switching; resistance treatment;