Precise measurement of molecular phenotypes with barcode-based CRISPRi systems
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DOI: 10.1186/s13059-025-03610-w
Abstract: Genome-wide CRISPR-Cas9 screens have untangled regulatory networks driving diverse biological processes. Their success relies on interrogating specific molecular phenotypes and distinguishing key regulators from background effects. Here, we realize these goals by optimizing CRISPR interference… read more here.
Keywords: molecular phenotypes; barcode based; ciber seq; phenotypes barcode ... See more keywords