Phenotypic Classification of Multisystem Inflammatory Syndrome in Children Using Latent Class Analysis
Sign Up to like & getrecommendations! Published in 2025 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2024.56272
Abstract: Key Points Question Can phenotypic clusters of multisystem inflammatory syndrome in children (MIS-C) be identified, and are some clusters associated with increased severity? Findings In this cohort study, a latent class analysis was conducted on… read more here.
Keywords: class analysis; inflammatory syndrome; multisystem inflammatory; syndrome children ... See more keywords
Convergence and Divergence of Rare Genetic Disorders on Brain Phenotypes: A Review.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2022.1450
Abstract: Importance Rare genetic disorders modulating gene expression-as exemplified by gene dosage disorders (GDDs)-represent a collectively common set of high-risk factors for neuropsychiatric illness. Research on GDDs is rapidly expanding because these variants have high effect… read more here.
Keywords: genetic disorders; convergence divergence; brain; rare genetic ... See more keywords
Psychoses of Epilepsy: Unravelling the Phenotypic and Genotypic Features
Sign Up to like & getrecommendations! Published in 2025 at "Annals of Neurology"
DOI: 10.1002/ana.27209
Abstract: We analyzed the genotypic and phenotypic features of patients with psychosis of epilepsy (POE). read more here.
Keywords: phenotypic; unravelling phenotypic; psychoses epilepsy; genotypic ... See more keywords
Extraction of phenotypic traits from taxonomic descriptions for the tree of life using natural language processing
Sign Up to like & getrecommendations! Published in 2018 at "Applications in Plant Sciences"
DOI: 10.1002/aps3.1035
Abstract: Premise of the Study Phenotypic data sets are necessary to elucidate the genealogy of life, but assembling phenotypic data for taxa across the tree of life can be technically challenging and prohibitively time consuming. We… read more here.
Keywords: taxonomic descriptions; phenotypic; natural language; tree life ... See more keywords
Genotypic confirmation of a biased phenotypic sex ratio in a dryland moss using restriction fragment length polymorphisms
Sign Up to like & getrecommendations! Published in 2022 at "Applications in Plant Sciences"
DOI: 10.1002/aps3.11467
Abstract: Abstract Premise In dioicous mosses, sex is determined by a single U (female, ♀) or V (male, ♂) chromosome. Although a 1 : 1 sex ratio is expected following meiosis, phenotypic sex ratios based on… read more here.
Keywords: phenotypic sex; sex expression; sex ratio; sex ... See more keywords
Proteomic workflows for deep phenotypic profiling of 3D organotypic liver models
Sign Up to like & getrecommendations! Published in 2024 at "Biotechnology Journal"
DOI: 10.1002/biot.202300684
Abstract: Organotypic human tissue models constitute promising systems to facilitate drug discovery and development. They allow to maintain native cellular phenotypes and functions, which enables long‐term pharmacokinetic and toxicity studies, as well as phenotypic screening. To… read more here.
Keywords: proteomic workflows; deep phenotypic; phenotypic profiling; workflows deep ... See more keywords
Molecular and phenotypic characteristics influencing the degree of cytoreduction in high-grade serous ovarian carcinomas.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.6085
Abstract: BACKGROUND High-grade serous ovarian carcinoma (HGSOC) is the deadliest ovarian cancer subtype, and survival relates to initial cytoreductive surgical treatment. The existing tools for surgical outcome prediction remain inadequate for anticipating the outcomes of the… read more here.
Keywords: high grade; grade serous; hgsoc; serous ovarian ... See more keywords
Identification of Biologically Diverse Tetrahydronaphthalen‐2‐ols through the Synthesis and Phenotypic Profiling of Chemically Diverse, Estradiol‐Inspired Compounds
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202200555
Abstract: Combining natural product fragments to design new scaffolds with unprecedented bioactivity is a powerful strategy for the discovery of tool compounds and potential therapeutics. However, the choice of fragments to couple and the biological screens… read more here.
Keywords: diverse tetrahydronaphthalen; tetrahydronaphthalen ols; biologically diverse; phenotypic ... See more keywords
Development of a Focused Library of Triazole‐Linked Privileged‐Structure‐Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections
Sign Up to like & getrecommendations! Published in 2018 at "ChemMedChem"
DOI: 10.1002/cmdc.201700786
Abstract: Protozoan infections caused by Plasmodium, Leishmania, and Trypanosoma spp. contribute significantly to the burden of infectious diseases worldwide, causing severe morbidity and mortality. The inadequacy of available treatments calls for cost‐ and time‐effective drug discovery… read more here.
Keywords: library triazole; triazole linked; focused library; phenotypic ... See more keywords
The relative contribution of drift and selection to phenotypic divergence: A test case using the horseshoe bats Rhinolophus simulator and Rhinolophus swinnyi
Sign Up to like & getrecommendations! Published in 2017 at "Ecology and Evolution"
DOI: 10.1002/ece3.2966
Abstract: Abstract Natural selection and drift can act on populations individually, simultaneously or in tandem and our understanding of phenotypic divergence depends on our ability to recognize the contribution of each. According to the quantitative theory… read more here.
Keywords: phenotypic divergence; rhinolophus; phenotypic; drift selection ... See more keywords
Environmental correlates of geographic divergence in a phenotypic trait: A case study using bat echolocation
Sign Up to like & getrecommendations! Published in 2017 at "Ecology and Evolution"
DOI: 10.1002/ece3.3251
Abstract: Abstract Divergence in phenotypic traits may arise from the interaction of different evolutionary forces, including different kinds of selection (e.g., ecological), genetic drift, and phenotypic plasticity. Sensory systems play an important role in survival and… read more here.
Keywords: variation; echolocation; phenotypic; divergence phenotypic ... See more keywords