Convergence and Divergence of Rare Genetic Disorders on Brain Phenotypes: A Review.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2022.1450
Abstract: Importance Rare genetic disorders modulating gene expression-as exemplified by gene dosage disorders (GDDs)-represent a collectively common set of high-risk factors for neuropsychiatric illness. Research on GDDs is rapidly expanding because these variants have high effect… read more here.
Keywords: genetic disorders; convergence divergence; brain; rare genetic ... See more keywords
Extraction of phenotypic traits from taxonomic descriptions for the tree of life using natural language processing
Sign Up to like & getrecommendations! Published in 2018 at "Applications in Plant Sciences"
DOI: 10.1002/aps3.1035
Abstract: Premise of the Study Phenotypic data sets are necessary to elucidate the genealogy of life, but assembling phenotypic data for taxa across the tree of life can be technically challenging and prohibitively time consuming. We… read more here.
Keywords: taxonomic descriptions; phenotypic; natural language; tree life ... See more keywords
Genotypic confirmation of a biased phenotypic sex ratio in a dryland moss using restriction fragment length polymorphisms
Sign Up to like & getrecommendations! Published in 2022 at "Applications in Plant Sciences"
DOI: 10.1002/aps3.11467
Abstract: Abstract Premise In dioicous mosses, sex is determined by a single U (female, ♀) or V (male, ♂) chromosome. Although a 1 : 1 sex ratio is expected following meiosis, phenotypic sex ratios based on… read more here.
Keywords: phenotypic sex; sex expression; sex ratio; sex ... See more keywords
Molecular and phenotypic characteristics influencing the degree of cytoreduction in high-grade serous ovarian carcinomas.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.6085
Abstract: BACKGROUND High-grade serous ovarian carcinoma (HGSOC) is the deadliest ovarian cancer subtype, and survival relates to initial cytoreductive surgical treatment. The existing tools for surgical outcome prediction remain inadequate for anticipating the outcomes of the… read more here.
Keywords: high grade; grade serous; hgsoc; serous ovarian ... See more keywords
Identification of Biologically Diverse Tetrahydronaphthalen‐2‐ols through the Synthesis and Phenotypic Profiling of Chemically Diverse, Estradiol‐Inspired Compounds
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202200555
Abstract: Combining natural product fragments to design new scaffolds with unprecedented bioactivity is a powerful strategy for the discovery of tool compounds and potential therapeutics. However, the choice of fragments to couple and the biological screens… read more here.
Keywords: diverse tetrahydronaphthalen; tetrahydronaphthalen ols; biologically diverse; phenotypic ... See more keywords
Development of a Focused Library of Triazole‐Linked Privileged‐Structure‐Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections
Sign Up to like & getrecommendations! Published in 2018 at "ChemMedChem"
DOI: 10.1002/cmdc.201700786
Abstract: Protozoan infections caused by Plasmodium, Leishmania, and Trypanosoma spp. contribute significantly to the burden of infectious diseases worldwide, causing severe morbidity and mortality. The inadequacy of available treatments calls for cost‐ and time‐effective drug discovery… read more here.
Keywords: library triazole; triazole linked; focused library; phenotypic ... See more keywords
The relative contribution of drift and selection to phenotypic divergence: A test case using the horseshoe bats Rhinolophus simulator and Rhinolophus swinnyi
Sign Up to like & getrecommendations! Published in 2017 at "Ecology and Evolution"
DOI: 10.1002/ece3.2966
Abstract: Abstract Natural selection and drift can act on populations individually, simultaneously or in tandem and our understanding of phenotypic divergence depends on our ability to recognize the contribution of each. According to the quantitative theory… read more here.
Keywords: phenotypic divergence; rhinolophus; phenotypic; drift selection ... See more keywords
Environmental correlates of geographic divergence in a phenotypic trait: A case study using bat echolocation
Sign Up to like & getrecommendations! Published in 2017 at "Ecology and Evolution"
DOI: 10.1002/ece3.3251
Abstract: Abstract Divergence in phenotypic traits may arise from the interaction of different evolutionary forces, including different kinds of selection (e.g., ecological), genetic drift, and phenotypic plasticity. Sensory systems play an important role in survival and… read more here.
Keywords: variation; echolocation; phenotypic; divergence phenotypic ... See more keywords
Low genetic diversity contrasts with high phenotypic variability in heptaploid Spartina densiflora populations invading the Pacific coast of North America
Sign Up to like & getrecommendations! Published in 2018 at "Ecology and Evolution"
DOI: 10.1002/ece3.4063
Abstract: Abstract Species can respond to environmental pressures through genetic and epigenetic changes and through phenotypic plasticity, but few studies have evaluated the relationships between genetic differentiation and phenotypic plasticity of plant species along changing environmental… read more here.
Keywords: phenotypic variability; genetic diversity; phenotypic; densiflora ... See more keywords
Evolution of adult male horn developmental phenotypes and character displacement in Xylotrupes beetles (Scarabaeidae)
Sign Up to like & getrecommendations! Published in 2021 at "Ecology and Evolution"
DOI: 10.1002/ece3.7448
Abstract: Abstract Character displacement that leads to divergent phenotypes between sympatric species has been hypothesized to facilitate coexistence and promote the accumulation of biodiversity. However, there are alternative evolutionary mechanisms that may also lead to the… read more here.
Keywords: male horn; evolution; sympatric species; character displacement ... See more keywords
Phenotypic dissimilarity index: Correcting for intra and interindividual variability when quantifying phenotypic variation.
Sign Up to like & getrecommendations! Published in 2022 at "Ecology"
DOI: 10.1002/ecy.3806
Abstract: In trait-based ecology, phenotypic variation (PVar) is often quantified with measures expressing average differences between populations standardized in the range 0-1. However, these measures disregard the within-population trait variability. In addition, some of them cannot… read more here.
Keywords: index; ecology; trait; variability ... See more keywords