A suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like Cryptosporidium growth inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09880-w
Abstract: Cryptosporidiosis is a leading cause of life-threatening diarrhea in children, and the only currently approved drug is ineffective in malnourished children and immunocompromised people. Large-scale phenotypic screens are ongoing to identify anticryptosporidial compounds, but optimal… read more here.
Keywords: suite phenotypic; assays ensure; pipeline; phenotypic ... See more keywords
Comparison of 11 Phenotypic Assays for Accurate Detection of Carbapenemase-Producing Enterobacteriaceae
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DOI: 10.1128/jcm.02338-16
Abstract: ABSTRACT Early identification of carbapenemase-producing Enterobacteriaceae (CPE) is essential to prevent their dissemination within health care settings. Our objective was to evaluate the accuracy of 11 phenotypic assays for the detection of CPE. Two collections… read more here.
Keywords: carbapenemase producing; detection; producing enterobacteriaceae; phenotypic ... See more keywords
Comparison of Six Phenotypic Assays with Reference Methods for Assessing Colistin Resistance in Clinical Isolates of Carbapenemase-Producing Enterobacterales: Challenges and Opportunities
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DOI: 10.3390/antibiotics11030377
Abstract: The global escalation of severe infections due to carbapenemase-producing Enterobacterales (CPE) isolates has prompted increased usage of parenteral colistin. Considering the reported difficulties in assessing their susceptibility to colistin, the purpose of the study was… read more here.
Keywords: producing enterobacterales; six phenotypic; phenotypic assays; colistin ... See more keywords
Comparison of Lateral Flow Immunochromatography and Phenotypic Assays to PCR for the Detection of Carbapenemase-Producing Gram-Negative Bacteria, a Multicenter Experience in Mexico
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DOI: 10.3390/antibiotics12010096
Abstract: The identification of carbapenemase-producing Enterobacterales and Pseudomonas aeruginosa is important for treating and controlling hospital infections. The recommended methods for their identification require a long waiting time, technical training, and expertise. Lateral flow immunoassays such… read more here.
Keywords: test carba; lateral flow; phenotypic assays; carbapenemase ... See more keywords
A Compact Imaging Platform for Conducting C. elegans Phenotypic Assays on Earth and in Spaceflight
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DOI: 10.3390/life13010200
Abstract: The model organism Caenorhabditis elegans is used in a variety of applications ranging from fundamental biological studies, to drug screening, to disease modeling, and to space-biology investigations. These applications rely on conducting whole-organism phenotypic assays… read more here.
Keywords: imaging platform; compact imaging; phenotypic assays; platform conducting ... See more keywords