Inversion frequencies and phenotypic effects are modulated by the environment: insights from a reciprocal transplant study in Coelopa frigida
Sign Up to like & getrecommendations! Published in 2018 at "Evolutionary Ecology"
DOI: 10.1007/s10682-018-9960-5
Abstract: Understanding how environmental variation drives phenotypic diversification within species is a major objective in evolutionary biology. The seaweed fly Coelopa frigida provides an excellent model for the study of genetically driven phenotypes because it carries… read more here.
Keywords: inversion; phenotypic effects; study; reciprocal transplant ... See more keywords
Phenotypic effects of paralogous ribosomal proteins bL31A and bL31B in E. coli
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-68582-2
Abstract: Ribosomes are essential macromolecular complexes conducting protein biosynthesis in all domains of life. Cells can have heterogeneous ribosomes, i.e. ribosomes with various ribosomal RNA and ribosomal protein (r-protein) composition. However, the functional importance of heterogeneous… read more here.
Keywords: effects paralogous; phenotypic effects; bl31a bl31b; ribosomal protein ... See more keywords
Bacterial Hsp90 predominantly buffers but does not potentiate the phenotypic effects of deleterious mutations during fluorescent protein evolution.
Sign Up to like & getrecommendations! Published in 2022 at "Genetics"
DOI: 10.1093/genetics/iyac154
Abstract: Chaperones facilitate the folding of other ("client") proteins, and can thus affect the adaptive evolution of these clients. Specifically, chaperones affect the phenotype of proteins via two opposing mechanisms. On the one hand, they can… read more here.
Keywords: hsp90; fluorescent protein; evolution; phenotypic effects ... See more keywords
Understanding molecular mechanisms and predicting phenotypic effects of pathogenic tubulin mutations
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Computational Biology"
DOI: 10.1101/2022.06.16.496400
Abstract: Cells rely heavily on microtubules for several processes, including cell division and molecular trafficking. Mutations in the different tubulin-α and -β proteins that comprise microtubules have been associated with various diseases and are often dominant,… read more here.
Keywords: mechanisms predicting; molecular mechanisms; tubulin mutations; understanding molecular ... See more keywords
Phenotypic effects of mutations observed in the neuraminidase of human origin H5N1 influenza A viruses
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1011135
Abstract: Global spread and regional endemicity of H5Nx Goose/Guangdong avian influenza viruses (AIV) pose a continuous threat for poultry production and zoonotic, potentially pre-pandemic, transmission to humans. Little is known about the role of mutations in… read more here.
Keywords: h5n1; influenza viruses; replication; human like ... See more keywords