Response to: Phenotypic heterogeneity of Leigh syndrome due to NDUFA12 variants is multicausal
Sign Up to like & getrecommendations! Published in 2021 at "Human Mutation"
DOI: 10.1002/humu.24303
Abstract: We thank Dr. Finsterer for the comments (Finsterer, 2021) regarding our manuscript (Torraco et al., 2021) and below you will find our responses to his concerns. First of all we agree that the sentence reported… read more here.
Keywords: response phenotypic; variability; leigh syndrome; phenotypic heterogeneity ... See more keywords
Assessing Phenotypic Heterogeneity in Intestinal Tissue Eosinophils.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1095-4_19
Abstract: Eosinophils are primarily tissue-dwelling leukocytes. Utilization of flow cytometry techniques applied to digested tissues is expanding the scope of organs within which eosinophils are identified at baseline and is providing deeper insights into categorizing phenotypically… read more here.
Keywords: assessing phenotypic; phenotypic heterogeneity; heterogeneity intestinal; tissue ... See more keywords
Genetics and phenotypic heterogeneity of Dent disease: the dark side of the moon
Sign Up to like & getrecommendations! Published in 2020 at "Human Genetics"
DOI: 10.1007/s00439-020-02219-2
Abstract: Dent disease is a rare genetic proximal tubulopathy which is under-recognized. Its phenotypic heterogeneity has led to several different classifications of the same disorder, but it is now widely accepted that the triad of symptoms… read more here.
Keywords: genetics; phenotypic heterogeneity; disease; dent disease ... See more keywords
The role of spatial variations of abiotic factors in mediating intratumour phenotypic heterogeneity.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2018.05.002
Abstract: We present here a space- and phenotype-structured model of selection dynamics between cancer cells within a solid tumour. In the framework of this model, we combine formal analyses with numerical simulations to investigate in silico… read more here.
Keywords: role spatial; geometry; phenotypic heterogeneity; phenotypic ... See more keywords
Environmental and phenotypic heterogeneity of populations at the trailing range-edge of the habitat-forming macroalga Fucus serratus.
Sign Up to like & getrecommendations! Published in 2018 at "Marine environmental research"
DOI: 10.1016/j.marenvres.2018.02.004
Abstract: Empirical work on the dynamics of range limits of species distributions often lack replications of edge populations. We compared the local environment and performance of two groups of geographically peripheral populations of the foundation intertidal… read more here.
Keywords: phenotypic heterogeneity; range; edge; fucus serratus ... See more keywords
Homogenizing bacterial cell factories: Analysis and engineering of phenotypic heterogeneity.
Sign Up to like & getrecommendations! Published in 2017 at "Metabolic engineering"
DOI: 10.1016/j.ymben.2017.06.009
Abstract: In natural habitats, microbes form multispecies communities that commonly face rapidly changing and highly competitive environments. Thus, phenotypic heterogeneity has evolved as an innate and important survival strategy to gain an overall fitness advantage over… read more here.
Keywords: engineering; phenotypic heterogeneity; heterogeneity; physiology ... See more keywords
Phenotypic heterogeneity of MELAS☆☆☆
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Genetics and Metabolism Reports"
DOI: 10.1016/j.ymgmr.2016.12.002
Abstract: With interest we read the article by Dvorakova et al. about 50 Czech patients carrying the m.3243ANG mutation [1]. It raises questions and concerns. Since MELAS is a progressive disease, we should be informed about… read more here.
Keywords: many patients; phenotypic heterogeneity; mutation; heterogeneity melas ... See more keywords
A riboswitch gives rise to multi-generational phenotypic heterogeneity in an auxotrophic bacterium
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-15017-1
Abstract: Auxotrophy, the inability to produce an organic compound essential for growth, is widespread among bacteria. Auxotrophic bacteria rely on transporters to acquire these compounds from their environment. Here, we study the expression of both low-… read more here.
Keywords: phenotypic heterogeneity; met transporter; high affinity; affinity ... See more keywords
Bidirectional Genetic Control of Phenotypic Heterogeneity and Its Implication for Cancer Drug Resistance
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msaa332
Abstract: Abstract Negative genetic regulators of phenotypic heterogeneity, or phenotypic capacitors/stabilizers, elevate population average fitness by limiting deviation from the optimal phenotype and increase the efficacy of natural selection by enhancing the phenotypic differences among genotypes.… read more here.
Keywords: phenotypic heterogeneity; control; phenotypic; resistance ... See more keywords
Substrate and electron donor limitation induce phenotypic heterogeneity in different metabolic activities in a green sulphur bacterium
Sign Up to like & getrecommendations! Published in 2018 at "Environmental Microbiology Reports"
DOI: 10.1111/1758-2229.12616
Abstract: Populations of genetically identical cells can display marked variation in phenotypic traits; such variation is termed phenotypic heterogeneity. Here, we investigate the effect of substrate and electron donor limitation on phenotypic heterogeneity in N2 and… read more here.
Keywords: phenotypic heterogeneity; electron donor; heterogeneity; donor limitation ... See more keywords
Molecular analysis of phenotypic heterogeneity in JAK2V617F‐positive myeloproliferative neoplasms reveals a potential target for therapy
Sign Up to like & getrecommendations! Published in 2023 at "British Journal of Haematology"
DOI: 10.1111/bjh.18669
Abstract: JAK2V617F is the most frequent mutation in BCR‐ABL‐negative myeloproliferative neoplasms (MPNs). It is an important but not the only determinant of MPN phenotype. We performed high‐throughput sequencing on JAK2V617F+ essential thrombocythaemia (ET) and polycythaemia vera… read more here.
Keywords: jak2v617f; wnt catenin; analysis; phenotypic heterogeneity ... See more keywords