Melatonin‐Primed Mesenchymal Stem Cells‐Derived Small Extracellular Vesicles Alleviated Neurogenic Erectile Dysfunction by Reversing Phenotypic Modulation
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202203087
Abstract: Erectile dysfunction (ED) is an adverse side effect of pelvic surgery with no effective treatment. In this study, it is explored whether melatonin could improve the therapeutic effects of small extracellular vesicles (sEVs), derived from… read more here.
Keywords: extracellular vesicles; modulation; erectile dysfunction; phenotypic modulation ... See more keywords
High Mobility Group Box 1 Mediates Interferon‐γ‐Induced Phenotypic Modulation of Vascular Smooth Muscle Cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25682
Abstract: The phenotypic modulation of VSMCs is a key cellular event driving neointimal formation and vascular remodeling. As a multifaceted cytokine of cell‐mediated immunity, IFN‐γ has been shown to play a critical role in the pathogenesis… read more here.
Keywords: hmgb1; modulation; ifn; phenotypic modulation ... See more keywords
Endothelial Cells Inhibit the Angiotensin II Induced Phenotypic Modulation of Rat Vascular Adventitial Fibroblasts
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25941
Abstract: The phenotypic modulation of vascular adventitial fibroblasts plays an important role in vascular remodeling. Evidence have shown that endothelial cells and adventitial fibroblasts interact under certain conditions. In this study, we investigated the influence of… read more here.
Keywords: adventitial fibroblasts; vascular adventitial; endothelial cells; phenotypic modulation ... See more keywords
miR‐4735‐3p regulates phenotypic modulation of vascular smooth muscle cells by targeting HIF‐1‐mediated autophagy in intracranial aneurysm
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29219
Abstract: Intracranial aneurysm (IA) is recognized as a lethal form of cerebrovascular disease mainly featured with a modulated phenotype of vascular smooth muscle cells (SMCs). It is generally believed that enhanced SMC proliferation and migration capabilities… read more here.
Keywords: proliferation migration; hif; mir; smc proliferation ... See more keywords
Shear Stress Induces Phenotypic Modulation of Vascular Smooth Muscle Cells via AMPK/mTOR/ULK1-Mediated Autophagy
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-017-0505-1
Abstract: Phenotypic modulation of vascular smooth muscle cells (VSMCs) is involved in the pathophysiological processes of the intracranial aneurysms (IAs). Although shear stress has been implicated in the proliferation, migration, and phenotypic conversion of VSMCs, the… read more here.
Keywords: stress; ampk mtor; shear stress; phenotypic modulation ... See more keywords
Phenotypic modulation of vascular smooth muscle cells in the corpus spongiosum surrounding the urethral plate in hypospadias
Sign Up to like & getrecommendations! Published in 2022 at "Andrologia"
DOI: 10.1111/and.14540
Abstract: Hypospadias is an abnormal ventral development of the penis caused by incomplete virilization of the male genital tubercle. This study investigated the phenotypic modulation of vascular smooth muscle cells (VSMCs) in the corpus spongiosum surrounding… read more here.
Keywords: phenotypic modulation; vascular smooth; corpus spongiosum; smooth muscle ... See more keywords
Embryologic Origin Influences Smooth Muscle Cell Phenotypic Modulation Signatures in Murine Marfan Syndrome Aortic Aneurysm
Sign Up to like & getrecommendations! Published in 2022 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.122.317381
Abstract: Background: Aortic root smooth muscle cells (SMC) develop from both the second heart field (SHF) and neural crest. Disparate responses to disease-causing Fbn1 variants by these lineages are proposed to promote focal aortic root aneurysm… read more here.
Keywords: aortic root; phenotypic modulation; aneurysm; smooth muscle ... See more keywords
Biomarkers in VSMC phenotypic modulation and vascular remodeling.
Sign Up to like & getrecommendations! Published in 2019 at "Die Pharmazie"
DOI: 10.1691/ph.2019.9743
Abstract: Vascular smooth muscle cells (VSMCs) are not terminally differentiated and can change their phenotype in response to environmental cues. Phenotype switching of VSMCs to less differentiated forms has led to an underestimation of their role… read more here.
Keywords: phenotypic modulation; vascular remodeling; modulation vascular; vsmc phenotypic ... See more keywords
Protective role of cytochrome c oxidase 5A (COX5A) against mitochondrial disorder and oxidative stress in VSMC phenotypic modulation and neointima formation.
Sign Up to like & getrecommendations! Published in 2023 at "Current vascular pharmacology"
DOI: 10.2174/1570161121666230315142507
Abstract: BACKGROUND The pathological role of cytochrome c oxidase 5A (COX5A) in vascular neointima formation remains unknown. AIM This study aims to investigate the role of COX5A on Platelet-derived growth factor BB (PDGF-BB)-mediated smooth muscle phenotypic… read more here.
Keywords: role; phenotypic modulation; cox5a; neointima formation ... See more keywords
Phenotypic Modulation of Cancer-Associated Antioxidant NQO1 Activity by Post-Translational Modifications and the Natural Diversity of the Human Genome
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DOI: 10.3390/antiox12020379
Abstract: Human NAD(P)H:quinone oxidoreductase 1 (hNQO1) is a multifunctional and antioxidant stress protein whose expression is controlled by the Nrf2 signaling pathway. hNQO1 dysregulation is associated with cancer and neurological disorders. Recent works have shown that… read more here.
Keywords: translational modifications; modulation cancer; post translational; phenotypic modulation ... See more keywords