Phenotypic plasticity including drug efflux drives reversible irinotecan resistance in LIM1215 colorectal cancer cells.
Sign Up to like & getrecommendations! Published in 2025 at "FEBS letters"
DOI: 10.1002/1873-3468.70208
Abstract: Colorectal cancer (CRC) presents significant therapeutic challenges, particularly due to the development of resistance to standard chemotherapeutic agents such as irinotecan. In this study, we aimed to investigate the molecular and phenotypic mechanisms underlying irinotecan… read more here.
Keywords: colorectal cancer; phenotypic plasticity; resistance; irinotecan resistance ... See more keywords
Epigenetic and Transcriptional Variability Shape Phenotypic Plasticity
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DOI: 10.1002/bies.201700148
Abstract: Epigenetic and transcriptional variability contribute to the vast diversity of cellular and organismal phenotypes and are key in human health and disease. In this review, we describe different types, sources, and determinants of epigenetic and… read more here.
Keywords: epigenetic transcriptional; phenotypic plasticity; variability; transcriptional variability ... See more keywords
Phenotypic convergence of artificially reared and wild trout is mediated by shape plasticity
Sign Up to like & getrecommendations! Published in 2017 at "Ecology and Evolution"
DOI: 10.1002/ece3.3156
Abstract: Abstract Phenotypic plasticity can be viewed as the first level of defense of organism homeostasis against environmental stress and therefore represents the potential to deal with rapid environmental changes. Transitions between low complexity, artificial environments… read more here.
Keywords: shape plasticity; shape; trout; phenotypic plasticity ... See more keywords
Phenotypic plasticity of four Chenopodiaceae species with contrasting saline–sodic tolerance in response to increased salinity–sodicity
Sign Up to like & getrecommendations! Published in 2019 at "Ecology and Evolution"
DOI: 10.1002/ece3.4515
Abstract: Abstract It is unknown whether phenotypic plasticity in fitness‐related traits is associated with salinity–sodicity tolerance. This study compared growth and allocation phenotypic plasticity in two species with low salinity–sodicity tolerance (Chenopodium acuminatum and C. stenophyllum)… read more here.
Keywords: tolerance; phenotypic plasticity; plasticity; salinity sodicity ... See more keywords
Epigenetics underpins phenotypic plasticity of protandrous sex change in fish
Sign Up to like & getrecommendations! Published in 2022 at "Ecology and Evolution"
DOI: 10.1002/ece3.8730
Abstract: Abstract Phenotypic plasticity is an important driver of species resilience. Often mediated by epigenetic changes, phenotypic plasticity enables individual genotypes to express variable phenotypes in response to environmental change. Barramundi (Lates calcarifer) are a protandrous… read more here.
Keywords: change; length sex; phenotypic plasticity; sex ... See more keywords
A trait‐based framework for adaptive phenotypic plasticity under global change
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DOI: 10.1002/oik.11318
Abstract: Phenotypic plasticity is often regarded as a key mechanism for coping with environmental change, yet its adaptive potential remains uncertain in part because of inconsistencies in how environmental stressors are defined and studied, and the… read more here.
Keywords: phenotypic plasticity; framework; change; trait ... See more keywords
Temperature affects the relative importance of phenotypic plasticity and natural selection contributing to the niche breadth of invasive plants
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DOI: 10.1002/oik.11347
Abstract: Plant species adapt to changing climates through phenotypic plasticity and natural selection, affecting invasive plants' niche breadth. However, our limited understanding of how temperature affects the relative importance of phenotypic plasticity and natural selection contributes… read more here.
Keywords: phenotypic plasticity; natural selection; plasticity; niche breadth ... See more keywords
Phenotypic plasticity and developmental noise in hybrid and parental clones of Daphnia longispina complex
Sign Up to like & getrecommendations! Published in 2021 at "Aquatic Ecology"
DOI: 10.1007/s10452-021-09898-7
Abstract: According to the “temporal hybrid superiority hypothesis”, seasonal variability in environmental factors in temperate lakes gives hybrid clones within the D. longispina complex a temporary fitness advantage, thus allowing long-term, dynamic coexistence of hybrids and… read more here.
Keywords: developmental noise; phenotypic plasticity; daphnia; longispina complex ... See more keywords
Phenotypic Plasticity of Cuticular Hydrocarbon Profiles in Insects
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DOI: 10.1007/s10886-018-0934-4
Abstract: The insect integument is covered by cuticular hydrocarbons (CHCs) which provide protection against environmental stresses, but are also used for communication. Here we review current knowledge on environmental and insect-internal factors which shape phenotypic plasticity… read more here.
Keywords: insects; phenotypic plasticity; chc profiles; plasticity cuticular ... See more keywords
A Bayesian statistical analysis of stochastic phenotypic plasticity model of cancer cells.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2018.05.031
Abstract: The phenotypic plasticity of cancer cells has received special attention in recent years. Even though related models have been widely studied in terms of mathematical properties, a thorough statistical analysis on parameter estimation and model… read more here.
Keywords: cancer; model; phenotypic plasticity; cancer cells ... See more keywords
Phenotypic plasticity in relation to inter-cultivar variation of garlic (Allium sativum L.) functional performance and yield-stability in response to water availability
Sign Up to like & getrecommendations! Published in 2021 at "Scientia Horticulturae"
DOI: 10.1016/j.scienta.2021.110128
Abstract: Abstract Genetic diversity and adaptive functional responses of crops to limiting environmental conditions is crucial for sustainable agricultural production in a climate change scenario. Phenotypic plasticity and the study of stomata-related functional traits contribute to… read more here.
Keywords: phenotypic plasticity; response water; water availability; water ... See more keywords