Erratum to: Zebrafish phenotypic screen identifies novel Notch antagonists
Sign Up to like & getrecommendations! Published in 2017 at "Investigational New Drugs"
DOI: 10.1007/s10637-017-0437-0
Abstract: The authors would like to note that in the original online first version of this article, the symbol ɣ is missing from the text where ɣ-secretase is stated. Also, labels to figures in the Results… read more here.
Keywords: zebrafish phenotypic; phenotypic screen; identifies novel; screen identifies ... See more keywords
Phenotypic Screen for Cardiac Regeneration Identifies Molecules with Differential Activity in Human Epicardium-Derived Cells versus Cardiac Fibroblasts.
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DOI: 10.1021/acschembio.6b00683
Abstract: Activation and proliferation of resident cardiac progenitor cells has therapeutic potential to repair the heart after injury. However, research has been impeded by a lack of well-defined and characterized cell sources and difficulties in translation… read more here.
Keywords: phenotypic screen; human epicardium; epicardium derived; cardiac fibroblasts ... See more keywords
A Novel High-Content Phenotypic Screen To Identify Inhibitors of Mitochondrial DNA Maintenance in Trypanosomes
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DOI: 10.1128/aac.01980-21
Abstract: Kinetoplastid parasites cause diverse neglected diseases in humans and livestock, with an urgent need for new treatments. The survival of kinetoplastids depends on their uniquely structured mitochondrial genome (kDNA), the eponymous kinetoplast. ABSTRACT Kinetoplastid parasites… read more here.
Keywords: high content; content; content phenotypic; phenotypic screen ... See more keywords
Abstract LB-304: Discovery of chemical probe CCT251236: An orally bioavailable efficacious pirin ligand from an HSF1 phenotypic screen
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-lb-304
Abstract: Heat shock factor 1 (HSF1) was originally identified as a master regulator of the classical ‘cytoprotective’ heat shock response. However, a large body of evidence has now verified the importance of HSF1 to tumorigenesis and… read more here.
Keywords: phenotypic screen; probe; hsf1; pirin ... See more keywords