Organic Electronic Platform for Real-time Phenotypic Screening of Extracellular Vesicle-driven Breast Cancer Metastasis.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202301194
Abstract: Tumour-derived extracellular vesicles (TEVs) induce the epithelial-to-mesenchymal transition (EMT) in non-malignant cells to promote invasion and cancer metastasis, representing a novel therapeutic target in a field severely lacking in efficacious anti-metastasis treatments. However, scalable technologies… read more here.
Keywords: metastasis; platform; breast; cancer metastasis ... See more keywords
Phenotypic Screening of Histone Deacetylase (HDAC) Inhibitors against Schistosoma mansoni
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202100622
Abstract: Schistosomiasis is a prevalent yet neglected tropical parasitic disease caused by the Schistosoma genus of blood flukes. Praziquantel is the only currently available treatment, hence drug resistance poses a major threat. Recently, histone deacetylase 8… read more here.
Keywords: phenotypic screening; schistosoma mansoni; histone deacetylase; hdac inhibitors ... See more keywords
Genotypic-Phenotypic Screening of Galectin-3 in Relation to Risk Towards Rheumatoid Arthritis in North Indian Population.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of medical research"
DOI: 10.1016/j.arcmed.2019.07.011
Abstract: CONTEXT Galectin-3, a 35 kDa protein, is the only known member of chimera type galectin family. A growing body of evidences demonstrated the pro-inflammatory role of galectin-3 in the pathogenesis of Rheumatoid arthritis (RA). OBJECTIVES Keeping… read more here.
Keywords: screening galectin; genotypic phenotypic; galectin; phenotypic screening ... See more keywords
Phenotypic screening with target identification and validation in the discovery and development of E3 ligase modulators.
Sign Up to like & getrecommendations! Published in 2021 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2021.02.011
Abstract: The use of phenotypic screening was central to the discovery and development of novel thalidomide analogs, the IMiDs (immunomodulatory drugs) agents. With the discovery that these agents bind the E3 ligase, CRL4CRBN, and alter its… read more here.
Keywords: discovery development; phenotypic screening; discovery; screening target ... See more keywords
Next-Generation Phenotypic Screening in Early Drug Discovery for Infectious Diseases.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in parasitology"
DOI: 10.1016/j.pt.2019.05.004
Abstract: Cell-based phenotypic screening has proven to be valuable, notably in recapitulating relevant biological conditions, for example, the host cell/pathogen niche. However, the corresponding methodological complexity is not readily compatible with high-throughput pipelines, and fails to… read more here.
Keywords: discovery infectious; infectious diseases; phenotypic screening; discovery ... See more keywords
Old age-associated phenotypic screening for Alzheimer's disease drug candidates identifies sterubin as a potent neuroprotective compound from Yerba santa
Sign Up to like & getrecommendations! Published in 2019 at "Redox Biology"
DOI: 10.1016/j.redox.2018.101089
Abstract: Alzheimer's disease (AD) is the most frequent age-associated dementia with no treatments that can prevent or slow its progression. Since age is by far the major risk factor for AD, there is a strong rationale… read more here.
Keywords: age; alzheimer disease; phenotypic screening; biology ... See more keywords
Phenotypic Screening-Based Identification of 3,4-Disubstituted Piperidine Derivatives as Macrophage M2 Polarization Modulators: An Opportunity for Treating Multiple Sclerosis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01635
Abstract: Multiple sclerosis (MS) is a disease of the autoimmune-mediated disorder in the central nervous system, for which no effective therapeutic agent is currently available. The regulation of macrophage polarization toward M2 is a general benefit… read more here.
Keywords: macrophage polarization; polarization; phenotypic screening; multiple sclerosis ... See more keywords
Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00052
Abstract: Type 2 diabetes is marked by progressive β-cell failure, leading to loss of β-cell mass. Increased levels of circulating glucose and free fatty acids associated with obesity lead to β-cell glucolipotoxicity. There are currently no… read more here.
Keywords: molecules protect; glucolipotoxicity; cell; screening small ... See more keywords
Phenotypic Screening Using High-Content Imaging to Identify Lysosomal pH Modulators in a Neuronal Cell Model
Sign Up to like & getrecommendations! Published in 2022 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.1c00804
Abstract: Lysosomes are intracellular organelles responsible for the degradation of diverse macromolecules in a cell. A highly acidic pH is required for the optimal functioning of lysosomal enzymes. Loss of lysosomal intralumenal acidity can disrupt cellular… read more here.
Keywords: cell; lysosomal modulators; phenotypic screening; screening using ... See more keywords
Single-cell infrared phenomics: phenotypic screening with infrared microspectroscopy.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc05721e
Abstract: We conceptually demonstrate single-cell infrared phenomics as a novel strategy of phenotypic screening with infrared microspectroscopy. Based on this development, the cancer cell HepG2 glycocalyx was first identified as a potential target of protopanaxadiol, an… read more here.
Keywords: single cell; infrared phenomics; phenotypic screening; screening infrared ... See more keywords
A Phenotypic Screening Assay Identifies Modulators of Diamond Blackfan Anemia
Sign Up to like & getrecommendations! Published in 2019 at "SLAS Discovery"
DOI: 10.1177/2472555218823531
Abstract: Diamond-Blackfan anemia (DBA) is a bone marrow failure syndrome caused by mutations in ribosomal protein genes. Pathogenic mechanisms are poorly understood but involve severely reduced proliferation of erythroid precursors. Because current DBA therapies are ineffective… read more here.
Keywords: screening assay; phenotypic screening; blackfan anemia; diamond blackfan ... See more keywords