Cell Morphological Profiling Enables High-Throughput Screening for PROteolysis TArgeting Chimera (PROTAC) Phenotypic Signature
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DOI: 10.1101/2022.01.17.476610
Abstract: PROTACs (PROteolysis TArgeting Chimeras) use the ubiquitin-proteasome system to degrade a protein of interest for therapeutic benefit. Advances in targeted protein degradation technology have been remarkable with several molecules moving into clinical studies. However, robust… read more here.
Keywords: phenotypic signatures; cell; morphological profiling; phenotypic ... See more keywords
Identifying Cell Populations in Flow Cytometry Data Using Phenotypic Signatures
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DOI: 10.1109/tcbb.2016.2550428
Abstract: Single-cell flow cytometry is a technology that measures the expression of several cellular markers simultaneously for a large number of cells. Identification of homogeneous cell populations, currently done by manual biaxial gating, is highly subjective… read more here.
Keywords: cell populations; phenotypic signatures; flow cytometry; using phenotypic ... See more keywords