RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Cell"
DOI: 10.1016/j.ccell.2019.05.015
Abstract: Summary RAC1 P29 is the third most commonly mutated codon in human cutaneous melanoma, after BRAF V600 and NRAS Q61. Here, we study the role of RAC1P29S in melanoma development and reveal that RAC1P29S activates… read more here.
Keywords: melanoma; mesenchymal phenotypic; rac1p29s; resistance ... See more keywords
miR-125a-5p Modulates Phenotypic Switch of Vascular Smooth Muscle Cells by Targeting ETS-1.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2017.05.008
Abstract: MicroRNAs are key regulators of vascular smooth muscle cells (VSMCs) phenotypic switch, one of the main events responsible for bare metal in-stent restenosis after percutaneous coronary intervention. miR-125a-5p is an important modulator of differentiation, proliferation,… read more here.
Keywords: vsmcs; vascular smooth; smooth muscle; mir 125a ... See more keywords
A high-frequency phenotypic switch links bacterial virulence and environmental survival in Acinetobacter baumannii
Sign Up to like & getrecommendations! Published in 2018 at "Nature microbiology"
DOI: 10.1038/s41564-018-0151-5
Abstract: Antibiotic-resistant infections lead to 700,000 deaths per year worldwide1. The roles of phenotypically diverse subpopulations of clonal bacteria in the progression of diseases are unclear. We found that the increasingly pathogenic and antibiotic-resistant pathogen Acinetobacter… read more here.
Keywords: phenotypic switch; subpopulation; acinetobacter baumannii; acinetobacter ... See more keywords
Phenotypic switch of smooth muscle cells in paediatric chronic intestinal pseudo‐obstruction syndrome
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16367
Abstract: Smooth Muscle Cells (SMC) are unique amongst all muscle cells in their capacity to modulate their phenotype. Indeed, SMCs do not terminally differentiate but instead harbour a remarkable capacity to dedifferentiate, switching between a quiescent… read more here.
Keywords: chronic intestinal; muscle cells; smooth muscle; phenotypic switch ... See more keywords
IGFBP3 inhibits angiotensin II-induced aortic smooth muscle cell phenotypic switch and MMPs expression.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental physiology"
DOI: 10.1113/ep088927
Abstract: NEW FINDINGS What is the central question of this study? Insulin like growth factor (IGF) 1 and its major binding protein IGFBP3 involves in collagen deregulation in several cardiovascular diseases. The role of IGFBP3 in… read more here.
Keywords: expression; igfbp3; smooth muscle; phenotypic switch ... See more keywords
MiR-26a contributes to the PDGF-BB-induced phenotypic switch of vascular smooth muscle cells by suppressing Smad1
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.17998
Abstract: The phenotypic switch of vascular smooth muscle cells (VSMCs) is a key event in the pathogenesis of various vascular diseases, such as atherosclerosis and post-angioplasty restenosis. Small non-coding microRNAs (miRNAs) have emerged as critical modulators… read more here.
Keywords: switch vascular; mir 26a; vascular smooth; smooth muscle ... See more keywords
Establishing a Macrophage Phenotypic Switch-Associated Signature-Based Risk Model for Predicting the Prognoses of Lung Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.771988
Abstract: Background Tumor-associated macrophages are important components of the tumor microenvironment, and the macrophage phenotypic switch has been shown to correlate with tumor development. However, the use of a macrophage phenotypic switch-related gene (MRG)-based prognosis signature… read more here.
Keywords: risk; macrophage phenotypic; phenotypic switch; signature ... See more keywords
MALAT1: A Pivotal lncRNA in the Phenotypic Switch of Gastric Smooth Muscle Cells via the Targeting of the miR-449a/DLL1 Axis in Diabetic Gastroparesis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.719581
Abstract: Diabetic gastroparesis (DGP) is a common complication of diabetes mellitus (DM). Our previous study suggested that the expression of the long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is closely related to DGP.… read more here.
Keywords: phenotypic switch; mir 449a; 449a dll1; malat1 ... See more keywords