Non-invasive detection of narcolepsy type I phenotypical features and disease progression by continuous home-cage monitoring of activity in two mouse models: the HCRT-KO and DTA model.
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DOI: 10.1093/sleep/zsad144
Abstract: Narcolepsy type 1 (NT1) is a neurological disorder caused by disruption of hypocretin (HCRT; or orexin) neurotransmission leading to fragmented sleep/wake states, excessive daytime sleepiness (EDS), and cataplexy (abrupt muscle atonia during wakefulness). Electroencephalography and… read more here.
Keywords: home cage; phenotypical features; activity; model ... See more keywords