Comprehensive phenotyping of human platelets by single‐cell cytometry
Sign Up to like & getrecommendations! Published in 2022 at "Cytometry Part A"
DOI: 10.1002/cyto.a.24531
Abstract: Platelets are small anucleate blood cells that contribute to hemostasis, immunity, and inflammation. Circulating platelets are heterogeneous in size, age, receptor expression, and reactivity. They inherit many features from megakaryocytes and are further modified on… read more here.
Keywords: cell; human platelets; phenotyping human; single cell ... See more keywords
Evaluation of Icotinib as a Potent and Selective Inhibitor of Aldehyde Oxidase for Reaction Phenotyping in Human Hepatocytes
Sign Up to like & getrecommendations! Published in 2024 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.124.001693
Abstract: Aldehyde oxidase (AO) is a molybdenum cofactor-containing cytosolic enzyme that has gained prominence due to its involvement in the developmental failure of several drug candidates in first-in-human trials. Unlike cytochrome P450s (P450) and glucuronosyltransferase, AO… read more here.
Keywords: reaction; human hepatocytes; aldehyde oxidase; reaction phenotyping ... See more keywords