Design, synthesis and evaluation of 3-phenoxypyrazine-2-carboxamide derivatives as potent TGR5 agonists
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DOI: 10.1039/d1ra08867j
Abstract: TGR5 is emerging as an important and promising target for the treatment of non-alcoholic steatohepatitis, type 2 diabetes mellitus (T2DM), and obesity. A series of novel 3-phenoxypyrazine-2-carboxamide derivatives were designed, synthesized and evaluated in vitro… read more here.
Keywords: design synthesis; phenoxypyrazine carboxamide; evaluation phenoxypyrazine; carboxamide derivatives ... See more keywords