Structural Basis of 2-Phenylamino-4-phenoxyquinoline Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors
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DOI: 10.3390/molecules27020461
Abstract: New target molecules, namely, 2-phenylamino-4-phenoxyquinoline derivatives, were designed using a molecular hybridization approach, which was accomplished by fusing the pharmacophore structures of three currently available drugs: nevirapine, efavirenz, and rilpivirine. The discovery of disubstituted quinoline… read more here.
Keywords: phenoxyquinoline derivatives; potent hiv; phenylamino phenoxyquinoline; quinoline ... See more keywords