1,3,4‐Thiadiazole and 1,2,4‐triazole‐5‐thione derivatives bearing 2‐pentyl‐5‐phenyl‐2,4‐dihydro‐3H‐1,2,4‐triazole‐3‐one ring: Synthesis, molecular docking, urease inhibition, and crystal structure
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200355
Abstract: Two series of 1,3,4‐thiadiazole (40a–o) and 1,2,4‐triazole‐5‐thione (41a–l) derivatives bearing a 2‐pentyl‐5‐phenyl‐1,2,4‐triazole‐3‐one ring were synthesized and then studied for their urease inhibitory activities using thiourea as a standard drug. Among the two groups, the first… read more here.
Keywords: crystal; inhibition; activity; phenyl ... See more keywords
9,9-Bis[4-(N-aryl)phenyl]methylidene-xanthylidene Derivatives Displaying Mechano-, Crystallo-, and Thermochromism.
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DOI: 10.1002/cplu.202200360
Abstract: Tetraphenylethylene (TPE) derivatives bearing a xanthene moiety are of interest because they have novel optical properties. 9,9-Bis[4-(N,N-diphenylamino)phenyl] and 9,9-bis[4-(9-carbazolyl)-phenyl]methylidene-xanthylidenes 3 and 4 were synthesized using Suzuki-Miyaura coupling of 9,9-dibromomethylidene-xanthylidene with the corresponding boronic acids. Diphenylamino… read more here.
Keywords: aryl phenyl; xanthylidene; phenyl; phenyl methylidene ... See more keywords
Design, Synthesis, and Cytotoxicity Evaluation of 3-(5-(3-(aryl)-1-phenyl-1H-pyrazol-4-yl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)pyridine and 5-(3-(aryl)-1-phenyl-1H-pyrazol-4-yl)-3-(pyridin-3-yl)-4,5-dihydropyrazole-1-carbaldehyde Derivatives as Potential Anticancer Agents
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.2768
Abstract: In an attempt to find bio-active small molecules, a series of novel 3-(5-(3-(aryl)-1-phenyl-1H-pyrazol-4-yl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)pyridine 5a–i and 5-(3-(aryl)-1-phenyl-1H-pyrazol-4-yl)-3-(pyridin-3-yl)-4,5-dihydropyrazole-1-carbaldehyde 6a–i were designed, synthesized, and evaluated for their in vitro cytotoxic activity against a panel of human cancer cell… read more here.
Keywords: pyrazol; aryl phenyl; phenyl; cell ... See more keywords
Impact of position of electron withdrawing cyano groups on nonlinear optical properties of centrosymmetric donor-π-acceptor system
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DOI: 10.1002/qua.25441
Abstract: Two symmetrically substituted phenylenevinylene D-A-D′-A-D type siblings, (2Z,2′Z)-2,2′-(2,5-dimethoxy-1,4-phenylene)bis(3-(4-(dimethylamino)phenyl)acrylonitrile) (↑-dscn) and (2Z,2′Z)-3,3′-(2,5-dimethoxy-1,4-phenylene)bis(2-(4-(dimethylamino)phenyl)acrylonitrile) (↓-dscn), are prepared. We investigate the effect of different but symmetrical location of these cyano groups in vinylene bridges on the 1-photon and 2-photon… read more here.
Keywords: dscn; optical properties; cyano groups; phenyl ... See more keywords
Synthesis of a Fluorinated Derivative of Sigma-1 Receptor Modulator E1R: 2-[5-oxo-3-phenyl-2-(trifluoromethyl)pyrrolidin-1-yl]Acetamide
Sign Up to like & getrecommendations! Published in 2020 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-020-02814-1
Abstract: The ozonation of N-Boc-protected 3-methylidene-4-phenyl-5-(trifluoromethyl)pyrrolidin-2-one resulted in its transformation into 3-hydroxy-4-phenyl-5-(trifluoromethyl)-3-pyrrolin-2-one. Catalytic hydrogenation of its O-Boc-protected derivative introduced a way to reduce the double bond in combination with elimination of the hydroxy group leading to… read more here.
Keywords: phenyl trifluoromethyl; trifluoromethyl pyrrolidin; phenyl; synthesis fluorinated ... See more keywords
Synthesis, Characterization, Anti-corrosive/Anti-tumor Applications of a New Type Arylazo Compound 1,7-Bis(2-Hydroxy Phenyl)-4-(Phenyl Hydrazono)-Hepta-1,6-Diene-3,5-Dione
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Bio- and Tribo-Corrosion"
DOI: 10.1007/s40735-018-0183-7
Abstract: The purpose of the study is to synthesize and characterize a new arylazo compound 1,7-bis(2-hydroxyphenyl)-4-(phenylhydrazono)hepta-1,6-diene-3,5-dione (HPHDD) . The corrosion inhibition behavior of the compound on mild steel in 1 M HCl was investigated using weight loss… read more here.
Keywords: arylazo compound; diene dione; hepta diene; phenyl ... See more keywords
Synthesis, molecular docking, dynamic simulations, kinetic mechanism, cytotoxicity evaluation of N-(substituted-phenyl)-4-{(4-[(E)-3-phenyl-2-propenyl]-1-piperazinyl} butanamides as tyrosinase and melanin inhibitors: In vitro, in vivo and in silico approaches.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103445
Abstract: In the current research work, different N-(substituted-phenyl)-4-{(4-[(E)-3-phenyl-2-propenyl]-1-piperazinyl}butanamides have been synthesized according to the protocol described in scheme 1. The synthesis was initiated by reacting various substituted anilines (1a-e) with 4-chlorobutanoyl chloride (2) in aqueous basic… read more here.
Keywords: piperazinyl butanamides; phenyl propenyl; phenyl; phenyl phenyl ... See more keywords
Comparative biotoxicity of N-Phenyl-1-naphthylamine and N-Phenyl-2-naphthylamine on cyanobacteria Microcystis aeruginosa.
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DOI: 10.1016/j.chemosphere.2017.02.110
Abstract: N-Phenyl-1-naphthylamine (P1NA) and N-Phenyl-2-naphthylamine (P2NA) are both widely used as antioxidant and plant secondary metabolites. In this study, growth, esterase, photosynthetic activity and cell membrane integrity were used as biomarkers to compare biotoxicity of P1NA… read more here.
Keywords: p1na; p2na; microcystis aeruginosa; phenyl ... See more keywords
Quantification of 16 urinary biomarkers of exposure to flame retardants, plasticizers, and organophosphate insecticides for biomonitoring studies.
Sign Up to like & getrecommendations! Published in 2019 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2019.06.181
Abstract: Chlorinated alkyl and non-chlorinated aryl organophosphate flame retardants (OPFRs) and some brominated flame retardants (FR) were introduced as replacements for polybrominated diphenyl ethers (PBDEs) after PBDEs phase-out in 2004 and 2013. Organophosphorous (OP) insecticides are… read more here.
Keywords: general population; phosphate bis; phenyl; flame retardants ... See more keywords
Synthesis and characterization of diphenylamine derivative containing malononitrile for thermally activated delayed fluorescent emitter
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DOI: 10.1016/j.dyepig.2017.01.010
Abstract: Abstract To increase the efficiency of blue organic light-emitting diodes (OLEDs), new blue dopants, 2-(bis(4-(diphenylamino)phenyl)methylene)malononitrile (4-DPM) and 2-(bis(3-(diphenylamino)phenyl) methylene)malononitrile (3-DPM), with thermally activated delayed fluorescence were synthesized. 4-DPM with a p -phenyl linker between the… read more here.
Keywords: thermally activated; malononitrile; phenyl; activated delayed ... See more keywords
Alternating polymers based on alkoxy-phenyl substituted indacenodithiophene and fluorinated quinoxaline derivatives for photovoltaic cells
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DOI: 10.1016/j.dyepig.2017.06.023
Abstract: Abstract To effectively modulate the molecular energy levels of indacenodithiophene (IDT)-based donor-acceptor (D-A) polymers, 4-hexyloxy-phenyl and 3-fluorine-4-hexyloxy-phenyl substituted IDT derivatives were designed and copolymerized with fluorinated quinoxaline derivatives (0F, 1F and 2F) to construct a… read more here.
Keywords: alternating polymers; energy; phenyl; phenyl substituted ... See more keywords