Synthesis of fluorescent molecular switches based on porphyrinoids covalently linked with redox active ligands
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.131407
Abstract: Abstract 5,15-bis(1-hydoxy-2,6-di-tert-butyl-phenyl)10,20-bis-(pentaphenyl-phenyl)phenyl porphyrin and its Nickel complex were synthesized. Oxidation with NOBF4 gave 5,15bis(1-oxo-2,6-ditertairy-butyl-phenyl)10,20-bis(pentaphenyl-phenyl)phenyl-porphodimethene and Ni bis(1-oxo-2,6-ditertairy-butyl-phenyl)10,20-bis-(pentaphenylphenyl)phenyl porphodimethene. The porphyrin conjugates were characterized by NMR, mass, and UV-visible spectroscopy for structural elucidation. The density functional… read more here.
Keywords: fluorescent molecular; butyl phenyl; phenyl bis; phenyl ... See more keywords
Phenyl Bis-Sulfonamide Keap1-Nrf2 Protein–Protein Interaction Inhibitors with an Alternative Binding Mode
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c00457
Abstract: Inhibitors of Kelch-like ECH-associated protein 1 (Keap1) increase the activity of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) by stalling its ubiquitination and degradation. This enhances the expression of genes encoding proteins… read more here.
Keywords: protein protein; phenyl bis; protein interaction; keap1 nrf2 ... See more keywords