Synthesis and biological evaluation of 3-(2,4-dichlorophenoxymethyl)-1-phenyl-1H-pyrazole derivatives as potential antitumor agents
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-020-01951-w
Abstract: Series of novel 3-(2,4-dichlorophenoxymethyl)-1-phenyl-1H-pyrazole derivatives with various substituents at positions 4 and 5 were synthesized. Antitumor activity of all the synthesized compounds was evaluated by using SRB assay on four cell lines: lung carcinoma (A549),… read more here.
Keywords: pyrazole derivatives; cell lines; phenyl pyrazole; dichlorophenoxymethyl phenyl ... See more keywords
Discovery of N-(4-fluoro-2-(phenylamino)phenyl)-pyrazole-4-carboxamides as potential succinate dehydrogenase inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Pesticide biochemistry and physiology"
DOI: 10.1016/j.pestbp.2019.05.007
Abstract: Succinate dehydrogenase (SDH), an essential component of cellular respiratory chain and tricarboxylic acid (or Krebs) cycle, has been identified as one of the most significant targets for pharmaceutical and agrochemical. Herein, with the aim of… read more here.
Keywords: phenylamino phenyl; fluoro phenylamino; pyrazole carboxamides; phenyl pyrazole ... See more keywords
Spectroscopic, structural and photophysical characterization of chloro-bridged iridium(III) and rhodium(III) dinuclear complexes with 1-phenyl-1H-pyrazole and their analogues with 1-(2,4-difluorophenyl)-1H-pyrazole.
Sign Up to like & getrecommendations! Published in 2025 at "Dalton transactions"
DOI: 10.1039/d5dt01156f
Abstract: This paper deals with the synthesis and spectroscopic characterization of four important precursors, dinuclear [(C^N)2Ir-μ-Cl]2 and [(C^N)2Rh-μ-Cl]2 complexes, containing deprotonated 1-phenyl-1H-pyrazole or 1-(2,4-difluorophenyl)-1H-pyrazole as cyclometallating (C^N) ligands. The molecular structures of these μ-chloro-bridged complexes were… read more here.
Keywords: spectroscopic structural; iii; chloro bridged; characterization ... See more keywords
Synthesis and Antitumor Activities of Novel 5-amino-3-(halophenyl)- 1- phenyl-1H-pyrazole-4-carbonitriles.
Sign Up to like & getrecommendations! Published in 2024 at "Current organic synthesis"
DOI: 10.2174/0115701794259226231023091306
Abstract: In this work, a series of novel 3-(halophenyl)-1-phenyl-1H-pyrazole moieties have been synthesized. Their structures were characterized by IR, NMR, and MS spectroscopy, and the corresponding antitumor properties were also studied. OBJECTIVES This study aimed to… read more here.
Keywords: halophenyl phenyl; antitumor; cell; phenyl ... See more keywords
Multicomponent Synthesis of New Fluorescent Boron Complexes Derived from 3-Hydroxy-1-phenyl-1H-pyrazole-4-carbaldehyde
Sign Up to like & getrecommendations! Published in 2024 at "Molecules"
DOI: 10.3390/molecules29143432
Abstract: Novel fluorescent pyrazole-containing boron (III) complexes were synthesized employing a one-pot three-component reaction of 3-hydroxy-1-phenyl-1H-pyrazole-4-carbaldehyde, 2-aminobenzenecarboxylic acids, and boronic acids. The structures of the novel heterocyclic compounds were confirmed using 1H-, 13C-, 15N-, 19F-, and… read more here.
Keywords: phenyl pyrazole; pyrazole carbaldehyde; boron; hydroxy phenyl ... See more keywords