Antioxidant Properties and Aldehyde Reactivity of PD-L1 Targeted Aryl-Pyrazolone Anticancer Agents
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DOI: 10.3390/molecules27103316
Abstract: Small molecules targeting the PD-1/PD-L1 checkpoint are actively searched to complement the anticancer arsenal. Different molecular scaffolds have been reported, including phenyl-pyrazolone derivatives which potently inhibit binding of PD-L1 to PD-1. These molecules are structurally… read more here.
Keywords: aldehyde reactivity; reactivity; antioxidant properties; pyrazolone ... See more keywords
Novel PD-L1-Targeted Phenyl-Pyrazolone Derivatives with Antioxidant Properties
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28083491
Abstract: Orally-active anticancer small molecules targeting the PD-1/PD-L1 immune checkpoint are actively searched. Phenyl-pyrazolone derivatives with a high affinity for PD-L1 have been designed and characterized. In addition, the phenyl-pyrazolone unit acts as a scavenger of… read more here.
Keywords: targeted phenyl; novel targeted; antioxidant properties; pyrazolone ... See more keywords