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Published in 2018 at "Journal of The American Society for Mass Spectrometry"
DOI: 10.1007/s13361-018-2098-4
Abstract: AbstractCollisional activation fragmentation of protonated phosphorothioates leads to skeletal rearrangement and formation of aryl sulfenylium cation (R-PhS+) via successive eliminations of CH3OH and CH3O–P=O. To better understand this unusual fragmentation reaction, isotope-labeling experiments and density…
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Keywords:
atom;
ch3oh ch3o;
phenyl ring;
protonated phosphorothioates ... See more keywords
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Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.104282
Abstract: Cancer remains considered as one of the leading global health problems either due to meagre and suboptimal therapeutic response of chemotherapeutic agents or due to the emergence of spontaneous complex multidrug resistance in cancer cells.…
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Keywords:
trimethoxy phenyl;
ring pendant;
phenyl ring;
cancer ... See more keywords
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Published in 2019 at "Environmental science & technology"
DOI: 10.1021/acs.est.8b07050
Abstract: Reductive debromination has been widely studied for the degradation of polybrominated diphenyl ethers (PBDEs), although the reaction mechanisms are not so clear. In the present study, the photocatalytic degradation and debromination of ten PBDEs were…
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Keywords:
reductive debromination;
debromination;
polybrominated diphenyl;
phenyl ring ... See more keywords
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1
Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01215
Abstract: The benzene moiety is the most prevalent ring system in marketed drugs, underscoring its historic popularity in drug design either as a pharmacophore or as a scaffold that projects pharmacophoric elements. However, introspective analyses of…
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Keywords:
phenyl ring;
lead optimization;
chemistry;
drug design ... See more keywords
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Published in 2019 at "BMC Pharmacology & Toxicology"
DOI: 10.1186/s40360-019-0328-4
Abstract: BackgroundCushing’s syndrome is an endocrine disorder characterized by the overproduction of adrenocortical steroids. Steroidogenesis enzyme inhibitors are the mainstays of pharmacological treatment. Unfortunately, they produce significant side effects. Among the most potent inhibitors is the…
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Keywords:
etomidate;
phenyl ring;
etomidate analogs;
pharmacology ... See more keywords
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Published in 2021 at "Molecules"
DOI: 10.3390/molecules26071888
Abstract: Post-modification of a series of NCN-pincer platinum(II) complexes [PtX(NCN-R-4)] (NCN = [C6H2(CH2NMe2)2-2,6]–, R = C(O)H, C(O)Me and C(O)Et), X = Cl– or Br–) at the para-position using the McMurry reaction was studied. The synthetic route…
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Keywords:
pincer;
post modification;
phenyl ring;
ncn pincer ... See more keywords