Hit discovery of novel 2‐phenyl‐substituted 4‐amino–6,7‐dihydro‐5H‐cyclopenta[d]pyrimidines as potential anti‐glioblastoma therapeutics: Design, synthesis, biological evaluation, and computational screening
Sign Up to like & getrecommendations! Published in 2023 at "Drug Development Research"
DOI: 10.1002/ddr.22046
Abstract: Glioblastoma multiforme (GBM) is a highly‐aggressive, dreadful disease with poor prognosis and disappointing clinical success. There is an unmet medical need of molecularly‐targeted therapeutics for GBM treatment. In the present work, a series of novel… read more here.
Keywords: glioblastoma; dihydro cyclopenta; novel phenyl; amino dihydro ... See more keywords
Synthesis of 3-(4, 5-dihydro-1-phenyl-5-substituted phenyl-1H-pyrazol-3-yl)-2H-chromen-2-one derivatives and evaluation of their anticancer activity
Sign Up to like & getrecommendations! Published in 2017 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2013.09.008
Abstract: Abstract A novel series of 3-(4, 5-dihydro-1-phenyl-5-substituted phenyl-1H-pyrazol-3-yl)-2H-chromen-2-one derivatives were synthesized. In the first step salicylaldehyde was reacted with ethylacetoacetate at room temperature by stirring which gives compound (I). Compound (I) when refluxed with substituted… read more here.
Keywords: dihydro phenyl; anticancer activity; phenyl substituted; substituted phenyl ... See more keywords
Zinc complexes of 3-(ethylthio)phenyl-substituted phthalocyanines and naphthalocyanine: Synthesis and investigation of physicochemical properties
Sign Up to like & getrecommendations! Published in 2017 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2017.05.015
Abstract: Abstract Novel 3-(ethylthio)phenyl-substituted phthalocyanine and naphthalocyanine zinc complexes were synthesised with high yields. The Suzuki cross-coupling reaction provides selective approaches to the initial mono- or di- 3-(ethylthio)phenyl-substituted phthalonitriles. The complexes obtained were characterised by 1H… read more here.
Keywords: phthalocyanines naphthalocyanine; ethylthio phenyl; complexes ethylthio; zinc complexes ... See more keywords
Alternating polymers based on alkoxy-phenyl substituted indacenodithiophene and fluorinated quinoxaline derivatives for photovoltaic cells
Sign Up to like & getrecommendations! Published in 2017 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2017.06.023
Abstract: Abstract To effectively modulate the molecular energy levels of indacenodithiophene (IDT)-based donor-acceptor (D-A) polymers, 4-hexyloxy-phenyl and 3-fluorine-4-hexyloxy-phenyl substituted IDT derivatives were designed and copolymerized with fluorinated quinoxaline derivatives (0F, 1F and 2F) to construct a… read more here.
Keywords: alternating polymers; energy; phenyl; phenyl substituted ... See more keywords
Inhibitions of monoamine oxidases and acetylcholinesterase by 1-methyl, 5-phenyl substituted thiosemicarbazones: Synthesis, biochemical, and computational investigations
Sign Up to like & getrecommendations! Published in 2020 at "Process Biochemistry"
DOI: 10.1016/j.procbio.2020.05.016
Abstract: Abstract A series of eleven 1-methyl, 5-phenyl substituted thiosemicarbazones (MT1–MT11) with the phenyl ring substitutions were prepared and investigated for their inhibitory activities against monoamine oxidases (MAOs) and acetylcholinesterase (AChE). [4-(dimethylamino) phenyl]methylidene}-N-methylhydrazine-1-carbothioamide (MT5) inhibited MAO-B… read more here.
Keywords: inhibitions monoamine; monoamine oxidases; phenyl; phenyl substituted ... See more keywords
2-(Dimesitylboryl)phenyl-Substituted [2.2]Paracyclophanes Featuring Intense and Sign-Invertible Circularly Polarized Luminescence.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c02463
Abstract: We have disclosed a new type of [2.2]paracyclophanes that contain a 2-(dimesitylboryl)phenyl and a N,N-disubstituted amino groups at two different phenyl rings. They show intense circularly polarized luminescence combining high fluorescence efficiency (ΦF) and luminescence… read more here.
Keywords: dimesitylboryl phenyl; circularly polarized; sign; polarized luminescence ... See more keywords
Syntheses, crystal structures, and magnetic properties of cyclic dimer Ln2L2 complexes constructed from (3-pyridinylmethoxy)phenyl-substituted nitronyl nitroxide ligands
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DOI: 10.1039/c7ra06310e
Abstract: Herein, five lanthanide-radical cyclic dimer complexes [Ln(hfac)3(NIT-3PyPh)]2 derived from (3-pyridinylmethoxy)phenyl-substituted nitronyl nitroxide ligands, 2-(4-(3-pyridinylmethoxy)phenyl)-4,4,5,5-tetramethyl-imidazolyl-1-oxyl-3-oxide (NIT-3PyPh), and Ln(hfac)3 (LnIII = Gd (1), Tb (2), Dy (3), Ho (4), and Er (5); hfac = hexafluoroacetylacetonato), were synthesized… read more here.
Keywords: nitronyl nitroxide; cyclic dimer; substituted nitronyl; pyridinylmethoxy phenyl ... See more keywords
Phenyl-substituted aminomethylene-bisphosphonates inhibit human P5C reductase and show antiproliferative activity against proline-hyperproducing tumour cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2021.1919890
Abstract: Abstract In certain cancers, such as breast, prostate and some lung and skin cancers, the gene for the enzyme catalysing the second and last step in proline synthesis, δ1-pyrroline-5-carboxylate (P5C) reductase, has been found upregulated.… read more here.
Keywords: p5c reductase; tumour cells; phenyl substituted; proline ... See more keywords
Design and synthesis of new 1,2,3-triazole-pyrazole hybrids as antimicrobial agents
Sign Up to like & getrecommendations! Published in 2017 at "Russian Journal of General Chemistry"
DOI: 10.1134/s1070363217100280
Abstract: In the present study, a series of novel 1,2,3-triazoles derivatives (4a–4c) were synthesized by the 1,3-dipolar cycloaddition (click-reaction) of 1-phenyl-3-[2-(prop-2-yn-1-yloxy)phenyl substituted]-1H-pyrazole-4-carbaldehyade (3a–3c) with various aryl azides in the presence of sodium ascorbate and copper sulphate… read more here.
Keywords: triazole pyrazole; design synthesis; synthesis new; phenyl ... See more keywords
13C CPMAS NMR as a Tool for Full Structural Description of 2-Phenyl Substituted Imidazoles That Overcomes the Effects of Fast Tautomerization
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DOI: 10.3390/molecules25173770
Abstract: Tautomerization of 2-phenylimidazolecarbaldehydes has not been studied in detail so far, although this process is a well-known phenomenon for imidazole derivatives. That is why we focus our study on a series of 2-phenylimidazolecarbaldehydes and their… read more here.
Keywords: fast tautomerization; tautomerization; structural description; full structural ... See more keywords