Design, synthesis and structure-activity relationships of 4-phenyl-1H-1,2,3-triazole phenylalanine derivatives as novel HIV-1 capsid inhibitors with promising antiviral activities.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112085
Abstract: HIV-1 CA is involved in different stages of the viral replication cycle, performing essential roles in both early (uncoating, reverse transcription, nuclear import, integration) and late events (assembly). Recent efforts have demonstrated HIV-1 CA protein… read more here.
Keywords: design synthesis; phenyl triazole; phenylalanine derivatives; triazole phenylalanine ... See more keywords
Cationic Iridium Complexes with 5-Phenyl-1H-1,2,4-triazole Type Cyclometalating Ligands: Toward Blue-Shifted Emission.
Sign Up to like & getrecommendations! Published in 2019 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.9b01433
Abstract: Four cationic iridium complexes with 5-phenyl-1H-1,2,4-triazole (phtz) type cyclometalating ligands (C^N) and different ancillary ligands (N^N), namely, [Ir(dphtz)2(bpy)]PF6 (1), [Ir(dphtz)2(pzpy)]PF6 (2), [Ir(Mephtz)2(pzpy)]PF6 (3), and [Ir(Mephtz)2(dma-pzpy)]PF6 (4), have been designed, synthesized, and fully characterized (dphtz =… read more here.
Keywords: phenyl triazole; cationic iridium; iridium complexes; type ... See more keywords
Novel Strategy for Non-Aqueous Bioconjugation of Substituted Phenyl-1,2,4-triazole-3,5-dione Analogues
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27196667
Abstract: A novel 4-[4-(pentafluoro-λ⁶-sulfanyl)phenyl]-1,2,4-triazole-3,5-dione (5a) was synthesised as a potential [18F]radio-prosthetic group for radiolabelling peptides and proteins via selective bioconjugation with the phenolic side chains of tyrosine residues. Preliminary conjugation tests revealed the rapid hydrolysis of… read more here.
Keywords: phenyl triazole; triazole dione; ptad derivatives; bioconjugation ... See more keywords