PKU mutation p.G46S prevents the stereospecific binding of l‐phenylalanine to the dimer of human phenylalanine hydroxylase regulatory domain
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12175
Abstract: Mammalian phenylalanine hydroxylase (PAH) has a potential allosteric regulatory binding site for l‐phenylalanine (l‐Phe), in addition to its catalytic site. This arrangement is supported by a crystal structure of a homodimeric truncated form of the… read more here.
Keywords: hpah; regulatory domain; phenylalanine; phenylalanine hydroxylase ... See more keywords
Substituting Tyr138 in the active site loop of human phenylalanine hydroxylase affects catalysis and substrate activation
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DOI: 10.1002/2211-5463.12243
Abstract: Mammalian phenylalanine hydroxylase (PAH) is a key enzyme in l‐phenylalanine (l‐Phe) metabolism and is active as a homotetramer. Biochemical and biophysical work has demonstrated that it cycles between two states with a variably low and… read more here.
Keywords: phe; phenylalanine; phenylalanine hydroxylase; active site ... See more keywords
Highly selective recognition of L-phenylalanine with molecularly imprinted polymers based on imidazolyl amino acid chiral ionic liquid.
Sign Up to like & getrecommendations! Published in 2019 at "Chirality"
DOI: 10.1002/chir.23110
Abstract: Several amino acid chiral ionic liquids were introduced as functional monomers to prepare molecularly imprinted polymers for specific recognition of L-phenylalanine. Among them, the imprinted polymers L-Phe@MIPs based on [ViImC3][L-Pro] showed the best selective recognition… read more here.
Keywords: phe mips; adsorption; amino acid; recognition ... See more keywords
Relationships between tyrosine, phenylalanine, chlorogenic acid, and ascorbic acid concentrations and blackspot biochemical potential and blackspot susceptibility in stored russet potatoes.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.8884
Abstract: BACKGROUND Blackspot in potato is an internal tissue discoloration that occurs during handling and transport of potato tubers. Blackspot is cosmetically undesirable and represents a huge economic cost for the potato industry. The aim of… read more here.
Keywords: biochemical potential; blackspot; blackspot biochemical; phenylalanine ... See more keywords
Aromatic Zipper Topology Dictates Water-Responsive Actuation in Phenylalanine-Based Crystals.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202207773
Abstract: Water-responsive (WR) materials that reversibly deform in response to relative humidity (RH) changes are gaining increasing interest for their potential in energy harvesting and soft robotics applications. Despite progress, there are significant gaps in the… read more here.
Keywords: topology; phenylalanine; water; zipper topology ... See more keywords
Efficient synthesis of 2-phenylethanol from L-phenylalanine by engineered Bacillus licheniformis using molasses as carbon source
Sign Up to like & getrecommendations! Published in 2020 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-020-10740-7
Abstract: 2-Phenylethanol is a valuable flavoring agent with many applications. Although the bioproduction of 2-phenylethanol has been achieved by microbial fermentation, the low titer and high cost hinder its industrial-scale production. The goal of this study… read more here.
Keywords: phenylethanol; production; bacillus licheniformis; carbon source ... See more keywords
Allelopathic effects of exogenous phenylalanine: a comparison of four monocot species
Sign Up to like & getrecommendations! Published in 2017 at "Planta"
DOI: 10.1007/s00425-017-2720-x
Abstract: Main conclusionExogenous phenylalanine stunted annual ryegrass but not switchgrass or winter grain rye, with deuterium incorporation up to 3% from phenyalanine-d8. Toxicity to duckweed varied with illumination intensity and glucose uptake.Isotopic labeling of biomolecules through… read more here.
Keywords: switchgrass; annual ryegrass; allelopathic effects; phenylalanine ... See more keywords
Measurement of the 15N/14N ratio of phenylalanine in fermentation matrix by isotope ratio mass spectrometry
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology Letters"
DOI: 10.1007/s10529-017-2387-1
Abstract: AbstractObjectives To determine the origin of 15N-labeled phenylalanine in microbial metabolic flux analysis using 15N as a tracer, a method for measuring phenylalanine δ15N using HPLC coupled with elemental analysis-isotope ratio mass spectrometry (EA-IRMS) was… read more here.
Keywords: ratio mass; isotope ratio; ratio; phenylalanine ... See more keywords
Solubility and transformation behavior of l-phenylalanine anhydrate with amino acid additives
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Thermal Analysis and Calorimetry"
DOI: 10.1007/s10973-017-6641-5
Abstract: The solubility of l-phenylalanine in water with amino acid additives was experimentally studied by an analytical method. The data obtained were correlated by a semiempirical equation. Results showed that the solubility of l-phenylalanine increased with… read more here.
Keywords: amino acid; acid additives; transformation; phenylalanine anhydrate ... See more keywords
Increase of Bacillus badius Phenylalanine dehydrogenase specificity towards phenylalanine substrate by site-directed mutagenesis.
Sign Up to like & getrecommendations! Published in 2017 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2017.10.009
Abstract: Phenylalanine dehydrogenase (PheDH) is a key enzyme in medical diagnostic for determining the amount of phenylalanine to detect phenylketonuria (PKU) disease. However, determination of phenylalanine can be usually disturbed in presence of tyrosine in blood… read more here.
Keywords: directed mutagenesis; phenylalanine dehydrogenase; phenylalanine; site directed ... See more keywords
Selective recognition and determination of phenylalanine by a fluorescent probe based on cucurbit[8]uril and palmatine.
Sign Up to like & getrecommendations! Published in 2020 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2020.01.007
Abstract: This paper demonstrated a simple and validated fluorescence enhancing method to selectively recognize and discriminate the amino acid phenylalanine (Phe). 1H NMR spectroscopy reveal that the palmatine (PAL) can be encapsulated into the cucurbit [8]uril… read more here.
Keywords: fluorescence; cucurbit uril; phenylalanine; phe ... See more keywords