Identification and Characterization of an Efficient Phenylalanine Ammonia-Lyase from Photorhabdus luminescens
Sign Up to like & getrecommendations! Published in 2021 at "Applied Biochemistry and Biotechnology"
DOI: 10.1007/s12010-020-03477-6
Abstract: A putative aromatic amino acid ammonia-lyase gene (named Pl-pal) was discovered in Photorhabdus luminescens DSM 3368. BLAST and phylogenetic analyses predicted that this enzyme is a histidine ammonia-lyase, whereas sequence alignment suggested that it is… read more here.
Keywords: photorhabdus luminescens; phenylalanine ammonia; ammonia lyase; ammonia ... See more keywords
Substituted phosphonic analogues of phenylglycine as inhibitors of phenylalanine ammonia lyase from potatoes.
Sign Up to like & getrecommendations! Published in 2018 at "Biochimie"
DOI: 10.1016/j.biochi.2018.06.005
Abstract: A series of phosphonic acid analogues of phenylglycine variously substituted in phenyl ring have been synthesized and evaluated for their inhibitory activity towards potato l-phenylalanine ammonia lyase. Most of the compounds appeared to act as… read more here.
Keywords: analogues phenylglycine; site; phenylalanine ammonia; substituted phosphonic ... See more keywords
Cloning, characterization and expression of a phenylalanine ammonia-lyase gene (CcPAL) from cumin (Cuminum cyminum L.)
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Applied Research on Medicinal and Aromatic Plants"
DOI: 10.1016/j.jarmap.2020.100253
Abstract: Abstract Phenylalanine ammonia-lyase (PAL) that functions a substantial role in defense mechanisms, growth, and development of the plant, is situated at branching point from primary to secondary metabolism. In this study, using highly conserved sequences… read more here.
Keywords: cumin cuminum; cuminum cyminum; phenylalanine ammonia; gene ... See more keywords
l-Phenylalanine supplementation increases the production of phenylalanine ammonia-lyase and methyl cinnamate in the mycelia of Tricholoma matsutake
Sign Up to like & getrecommendations! Published in 2018 at "Mycoscience"
DOI: 10.1016/j.myc.2017.07.001
Abstract: Abstract We investigated changes in the expression of Tmpal1 and Tmpal2 , that encode phenylalanine ammonia-lyases (PALs), during the growth of Tricholoma matsutake NBRC 30605 mycelia, and the effect of exogenously added l -phenylalanine (… read more here.
Keywords: phenylalanine ammonia; methyl cinnamate; phenylalanine; tricholoma matsutake ... See more keywords
Preformulation studies with phenylalanine ammonia lyase: essential prelude to a microcapsule formulation for the management of phenylketonuria.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2022.03.016
Abstract: Phenylalanine ammonia lyase (PAL) metabolizes phenylalanine to transcinnamic acid (TCA). Our eventual goal is to develop a PAL microcapsule formulation to deplete phenylalanine in the gastrointestinal tract (g.i.t). The focus of this research is pre-formulation… read more here.
Keywords: formulation; ammonia lyase; phenylalanine ammonia; microcapsule formulation ... See more keywords
Phenylalanine ammonia lyase (PAL): From discovery to enzyme substitution therapy for phenylketonuria.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular genetics and metabolism"
DOI: 10.1016/j.ymgme.2018.06.002
Abstract: Phenylketonuria (PKU) is a genetic inborn error in metabolism that impacts many people globally, with profound individual and societal consequences when left untreated. The journey of phenylalanine ammonia lyase (PAL) from plant enzyme to enzyme… read more here.
Keywords: enzyme substitution; lyase pal; enzyme; phenylalanine ammonia ... See more keywords
Characterization of Phenylalanine Ammonia Lyases from Lettuce (Lactuca sativa L.) as Robust Biocatalysts for the Production of d- and l-Amino Acids.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c07890
Abstract: Phenylalanine ammonia lyase (PAL) catalyzes the reversible conversion of l-phenylalanine into the corresponding trans-cinnamic acid, providing a route to optically pure α-amino acids. We explored the catalytic function of all five PALs encoded in the… read more here.
Keywords: amino acids; phenylalanine; phenylalanine ammonia; lactuca sativa ... See more keywords
Zymophore identification enables the discovery of novel phenylalanine ammonia lyase enzymes
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13990-0
Abstract: The suite of biological catalysts found in Nature has the potential to contribute immensely to scientific advancements, ranging from industrial biotechnology to innovations in bioenergy and medical intervention. The endeavour to obtain a catalyst of… read more here.
Keywords: identification; phenylalanine ammonia; ammonia lyase;
Biochemical and Structural Analysis of Substrate Specificity of a Phenylalanine Ammonia-Lyase1
Sign Up to like & getrecommendations! Published in 2017 at "Plant Physiology"
DOI: 10.1104/pp.17.01608
Abstract: The major phenylalanine ammonia-lyases from Sorghum bicolor were characterized through crystal structures, molecular docking, site-directed mutagenesis, and kinetic and thermodynamic analyses. Phenylalanine ammonia-lyase (PAL) is the first enzyme of the general phenylpropanoid pathway catalyzing the… read more here.
Keywords: substrate specificity; phenylalanine ammonia; biochemical structural; ammonia ... See more keywords
Formulation and PEGylation optimization of the therapeutic PEGylated phenylalanine ammonia lyase for the treatment of phenylketonuria
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0173269
Abstract: Phenylketonuria (PKU) is a genetic metabolic disease in which the decrease or loss of phenylalanine hydroxylase (PAH) activity results in elevated, neurotoxic levels of phenylalanine (Phe). Due to many obstacles, PAH enzyme replacement therapy is… read more here.
Keywords: treatment; pal; phenylalanine ammonia; ravpal peg ... See more keywords
Changes in phenols composition and activity of phenylalanine-ammonia lyase in apples after fungal infections
Sign Up to like & getrecommendations! Published in 2018 at "Horticultural Science"
DOI: 10.17221/42/2010-hortsci
Abstract: Schovankova J., Opatova H., 2011. Changes in phenols composition and activity of phenylalanine-ammonia lyase in apples after fungal infections. Hort. Sci. (Prague), 38: 1–10. Th e defensive reaction of apple cultivar Idared (Malus domestica Borkh.)… read more here.
Keywords: activity phenylalanine; phenylalanine ammonia; ammonia lyase;