Scalable and Chromatography-Free Synthesis of Efflux Pump Inhibitor Phenylalanine Arginine β-Naphthylamide for its Validation in Wild-Type Bacterial Strains.
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DOI: 10.1002/cmdc.202300128
Abstract: Phenylalanine arginine β-naphthylamine, or PAβN, is a C-terminus capped dipeptide discovered as an RND-type efflux pump inhibitor (EPI) in 1999. Since then, PAβN has become a standard tool compound in EPI research and development. Despite… read more here.
Keywords: synthesis; efflux pump; phenylalanine arginine; type bacterial ... See more keywords
Activity of arginine-phenylalanine and arginine-tryptophan-based surfactants against Staphylococcus aureus.
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DOI: 10.2217/fmb-2022-0074
Abstract: Aims: This study aimed to evaluate the antibacterial effect of two new cationic surfactants based on phenylalanine-arginine (LPAM) and tryptophan-arginine (LTAM). Materials & methods: Antibacterial activity, mechanism of action and interactions with Staphylococcus aureus enzymes were measured… read more here.
Keywords: arginine; staphylococcus aureus; activity; tryptophan ... See more keywords
Phenylalanine-arginine β-naphthylamide could enhance neomycin-sensitivity on Riemerella anatipestifer in vitro and in vivo
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DOI: 10.3389/fmicb.2022.985789
Abstract: Riemerella anatipestifer is an important duck pathogen responsible for septicemia and infectious serositis, which has caused great economic losses to the duck industry. Phenylalanine-arginine β-naphthylamide (PAβN) is an efflux pump inhibitor, which mainly reduces the… read more here.
Keywords: vitro vivo; arginine naphthylamide; naphthylamide could; riemerella anatipestifer ... See more keywords
Boosting the Antibacterial Activity of Azithromycin on Multidrug-Resistant Escherichia coli by Efflux Pump Inhibition Coupled with Outer Membrane Permeabilization Induced by Phenylalanine-Arginine β-Naphthylamide
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DOI: 10.3390/ijms24108662
Abstract: The global spread of multidrug-resistant (MDR) bacteria increases the demand for the discovery of new antibiotics and adjuvants. Phenylalanine-arginine β-naphthylamide (PAβN) is an inhibitor of efflux pumps in Gram-negative bacteria, such as the AcrAB-TolC complex… read more here.
Keywords: arginine naphthylamide; escherichia coli; activity; multidrug resistant ... See more keywords